[Retracted] Transcriptome Comparison of Brain and Kidney Endothelial Cells in Homeostasis

Abstract

Endothelial cells are heterogeneous, stemming from multiple organs, but there is still little known about the connection between the brain and kidney endothelial cells, especially in homeostasis. In this study, scRNA-seq results were obtained to compare genetic profiles and biological features of tissue-specific endothelial cells. On this basis, seven endothelial cell subpopulations were identified, two of which were upregulated genes in pathways related to stroke and/or depression, as characterized by neuroinflammation. This study revealed the similarities and distinctions between brain and kidney endothelial cells, providing baseline information needed to fully understand the relationship between renal diseases and neuroinflammation, such as stroke and depression.

Endothelial Cells and Blood-Brain Barrier (BBB): The Key Factors in Ineffective Reperfusion Outcomes

“…Two predominant subsets of ECs in the brain, namely EC (Ptn) and EC (Col6a1), identified by their preferentially expressed genes, were juxtaposed with renal endothelial cells. These studies unveiled the positive role of three pathways in these subsets in the context of stroke and depression [16,18]. Furthermore, two genes -Ube2g1 and Pdcd4 -emerged as pivotal players in stroke development [16].…”

“…Notably, understanding the varied genetic expressions of brain ECs in relation to ECs of other organs within the BBB context bears significant implications for future research endeavors. Previous investigations [16,17] have particularly cataloged the distinctive EC compositions within both the brain and kidneys. Two predominant subsets of ECs in the brain, namely EC (Ptn) and EC (Col6a1), identified by their preferentially expressed genes, were juxtaposed with renal endothelial cells.…”

“…These studies unveiled the positive role of three pathways in these subsets in the context of stroke and depression [16,18]. Furthermore, two genes -Ube2g1 and Pdcd4 -emerged as pivotal players in stroke development [16]. Further research [19] explored the disparities in the immune complement system between these endothelial cells.…”

Retracted: Transcriptome Comparison of Brain and Kidney Endothelial Cells in Homeostasis

“…This article has been retracted by Hindawi following an investigation undertaken by the publisher [ 1 ]. This investigation has uncovered evidence of one or more of the following indicators of systematic manipulation of the publication process: Discrepancies in scope Discrepancies in the description of the research reported Discrepancies between the availability of data and the research described Inappropriate citations Incoherent, meaningless and/or irrelevant content included in the article Manipulated or compromised peer review …”

“…This article has been retracted by Hindawi following an investigation undertaken by the publisher [1]. This investigation has uncovered evidence of one or more of the following indicators of systematic manipulation of the publication process:…”