Transcriptome changes in newborn goats’ skeletal muscle as a result of maternal feed restriction at different stages of gestation

Costa, Thaís Correia; Mendes, Tiago Antônio de Oliveira; Santos, Marta Maria dos; Lopes, M. M.; Du, Min; Serão, Nick V. L.; Sanglard, Letícia P; Bertolini, Francesca; Rothschild, Max F.; Silva, Fabyano F.; Gionbelli, Mateus Pies; Duarte, Márcio de Souza

doi:10.1016/j.livsci.2021.104503

Cited by 3 publications

(3 citation statements)

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“…When the effects of maternal feed restriction during different stages of gestation on the newborn goat skeletal muscle transcriptome (Costa et al, 2021c) and proteome (Costa et al, 2022) were evaluated, it was observed that proteins exclusively expressed in each treatment (feed restriction in the first vs. last half of gestation) were present in both treatments at the transcriptional level. This suggested possible posttranscriptional regulation that repressed a set of genes in one of the treatments.…”

Section: Maternal Nutrition Effects On Epigenetic Mechanisms Underlyi...mentioning

confidence: 99%

Prenatal origins of productivity and quality of beef

Santos¹,

Costa²,

Ramírez-Zamudio³

et al. 2022

Revista Brasileira De Zootecnia

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RuminantsBoard-invited review Prenatal origins of productivity and quality of beef ABSTRACT -The productive traits of beef cattle are orchestrated by their genetics, postnatal environmental conditions, and also by the intrauterine background. Both under-or overnutrition, as specific dietary components, are able to promote persistent effects on the offspring. This occurs because dietary factors act not only affecting the availability of substrates for fetal anabolism and oxidative metabolism, but also as signals that regulate several events toward fetal development. Therefore, this study aimed to summarize the gestational nutrition effects on the offspring performance and meat quality in a long term. Overall, studies have shown that many of these alterations are under the control of epigenetic mechanisms, as DNA methylation, histones modification, and non-coding RNA. The current knowledge has indicated that the fetal programming responses are dependent on the window of fetal development in which the dietary treatment is applied, the intensity of maternal nutritional stimuli, and the treatment application length. Collectively, studies demonstrated that muscle cell hyperplasia is impaired when maternal requirements were not achieved in the second third of gestation, which limits the formation of a greater number of muscle fibers and the offspring growth potential in a long term. Changes in muscle fibers metabolism and in collagen content were also reported as consequence of a dietary perturbation during pregnancy. In contrast, a maternal overnutrition during the late pregnancy has been associated with beneficial responses on meat quality. In summary, ensuring an adequate maternal environment during the fetal development is crucial to enhance the productive responses in beef cattle operations.

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Section: Maternal Nutrition Effects On Epigenetic Mechanisms Underlyi...mentioning

confidence: 99%

Prenatal origins of productivity and quality of beef

Santos¹,

Costa²,

Ramírez-Zamudio³

et al. 2022

Revista Brasileira De Zootecnia

View full text Add to dashboard Cite

show abstract

“…Similarly, the energy restriction during late gestation contributes to the downregulation of genes involved in the oxidative metabolism, and consequently favoring the less efficient glycolytic metabolism in the skeletal muscle of calves ( Sanglard et al, 2018 ). Although no phenotypic differences were observed in the skeletal muscle of the newborn goats, resulting from maternal feed restriction at different stages of gestation ( Costa et al, 2019 ), the skeletal muscle transcriptome profile was altered, resulting in differentially expressed genes that are involved with skeletal muscle development and energy metabolism ( Costa et al, 2021b ).…”

Section: Fetal Programming and The Efficiency For The Deposition Of Muscle And Fatmentioning

confidence: 99%

Fetal programming in ruminant animals: understanding the skeletal muscle development to improve meat quality

2021

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“…The efficacy of maternal nutritional treatment applied at each stage of gestation was confirmed by maternal ADG and maternal tissue changes (Costa et al, 2019). Besides the lack of difference in birth weight (Costa et al, 2019), the skeletal muscle transcriptome (Costa et al, 2021c) and proteome (Costa et al, 2022) profile were altered due to the maternal feed restriction, indicating that the overall offspring development and metabolism were somehow altered to adapt to maternal nutritional status.…”

mentioning

confidence: 92%

Development of the gastrointestinal tract of newborn goats under maternal feed restriction at different stages of gestation

Santos,

Costa,

Souza

et al. 2023

Revista Brasileira De Zootecnia

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This study evaluated how nutritional insults applied at different stages of intrauterine development affect the growth and development of total tract organs and the mRNA expression of genes that encode growth factors, tight junction proteins, digestive enzymes, and glucose transporters in the small intestine of newborn goats. Fourteen nulliparous dairy goats were assigned to one of two nutritional plans over gestation: maintenance-restriction (M-R, n = 8) -100% of maintenance requirement from d 8-84 of gestation followed by feeding at 50% maintenance requirement from d 85 of gestation to parturition; or restriction-maintenance (R-M, n = 6) -50% of maintenance requirement from d 8-84 of gestation followed by feeding at 100% maintenance requirement from d 85 of gestation to parturition. Fisher's least significant difference test was performed using SAS 9.4, considering a full fixed-effect model. When expressed per kg of body weight, the weights of the small intestine and total intestine were 18.7 and 18.1% lower, respectively, for R-M offspring. The lengths of the small intestine and the total intestine of the R-M newborns were 19.1 and 9.5% shorter, respectively. This group also had a lower villus height:intestinal crypt depth ratio. The R-M offspring tended to have lower Solute carrier family 5 member 1 (SLC5A1), Solute carrier family 2 member 2 (SLC2A2), and Occludin (OCLN) mRNA expressions. Therefore, feed restriction in the first half of gestation is detrimental to the second half of gestation, reducing the offspring's intestinal absorptive area but enhancing their intestinal permeability.

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Transcriptome changes in newborn goats’ skeletal muscle as a result of maternal feed restriction at different stages of gestation

Cited by 3 publications

References 46 publications

Prenatal origins of productivity and quality of beef

Prenatal origins of productivity and quality of beef

Fetal programming in ruminant animals: understanding the skeletal muscle development to improve meat quality

Development of the gastrointestinal tract of newborn goats under maternal feed restriction at different stages of gestation

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