Transcriptome Based Estrogen Related Genes Biomarkers for Diagnosis and Prognosis in Non-small Cell Lung Cancer

Jia, Sinong; Li, Lei; Xie, Li; Zhang, Weituo; Zhu, Tengteng; Qian, Biyun

doi:10.3389/fgene.2021.666396

Cited by 10 publications

(9 citation statements)

References 93 publications

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“…Downregulation of FKBP3 suppressed breast cancer [ 81 ], and FKBP3 expression was associated with poor survival in LUAD [ 82 , 83 , 84 ]. Furthermore, FKBP4 was reported to be related to breast cancer [ 20 , 85 ], colorectal cancer [ 22 ], prostate cancer [ 86 ], and lung cancer [ 21 , 87 ]. FKBP10 was connected with gastric cancer [ 88 ], stomach adenocarcinomas [ 89 ], papillary thyroid cancer [ 90 ], and lung cancer.…”

Section: Discussionmentioning

confidence: 99%

Penetrating Exploration of Prognostic Correlations of the FKBP Gene Family with Lung Adenocarcinoma

Wang

Shen

Anuraga

et al. 2022

JPM

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The complexity of lung adenocarcinoma (LUAD), the development of which involves many interacting biological processes, makes it difficult to find therapeutic biomarkers for treatment. FK506-binding proteins (FKBPs) are composed of 12 members classified as conservative intracellular immunophilin family proteins, which are often connected to cyclophilin structures by tetratricopeptide repeat domains and have peptidyl prolyl isomerase activity that catalyzes proline from residues and turns the trans form into the cis form. Since FKBPs belong to chaperone molecules and promote protein folding, previous studies demonstrated that FKBP family members significantly contribute to the degradation of damaged, misfolded, abnormal, and foreign proteins. However, transcript expressions of this gene family in LUAD still need to be more fully investigated. In this research, we adopted high-throughput bioinformatics technology to analyze FKBP family genes in LUAD to provide credible information to clinicians and promote the development of novel cancer target drugs in the future. The current data revealed that the messenger (m)RNA levels of FKBP2, FKBP3, FKBP4, FKBP10, FKBP11, and FKBP14 were overexpressed in LUAD, and FKBP10 had connections to poor prognoses among LUAD patients in an overall survival (OS) analysis. Based on the above results, we selected FKBP10 to further conduct a comprehensive analysis of the downstream pathway and network. Through a DAVID analysis, we found that FKBP10 was involved in mitochondrial electron transport, NADH to ubiquinone transport, mitochondrial respiratory chain complex I assembly, etc. The MetaCore pathway analysis also indicated that FKBP10 was involved in "Ubiquinone metabolism", "Translation_(L)-selenoaminoacid incorporation in proteins during translation", and "Transcription_Negative regulation of HIF1A function". Collectively, this study revealed that FKBP family members are both significant prognostic biomarkers for lung cancer progression and promising clinical therapeutic targets, thus providing new targets for treating LUAD patients.

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Section: Discussionmentioning

confidence: 99%

Penetrating Exploration of Prognostic Correlations of the FKBP Gene Family with Lung Adenocarcinoma

Wang

Shen

Anuraga

et al. 2022

JPM

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“…LSCC is a common type of malignant tumour with a high burden of mortality, causing approximately 400,000 deaths worldwide every year 1 . In recent years, numerous studies have been conducted to explore the diagnosis, progression, prognosis and treatment of LSCC 31 , 32 . Some traditional tumor markers have been applied in screening, occurrence and prognosis prediction for LSCC 33 , including squamous cell carcinoma antigen (SCC), carcino-embryonic antigen (CEA), cytokeratins21-2 and neuron specific enolase (NSE).…”

Section: Discussionmentioning

confidence: 99%

Identification of pyroptosis-related long non-coding RNAs with prognosis and therapy in lung squamous cell carcinoma

Zhang

Wang²,

Yin

et al. 2022

Sci Rep

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Pyroptosis is a type of programmed cell death with an intense inflammatory response. Previous studies have shown that pyroptosis plays an important role in the pathogenesis and progression of lung cancer. However, the prognostic value and drug targets of pyroptosis-related lncRNAs in lung squamous cell carcinoma (LSCC) have never been studied. In the present study, we identified 1468 pyroptosis-related lncRNAs in LSCC by performing Pearson correlation analysis between the pyroptosis-related genes and the lncRNAs from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) database. The whole set was divided into a training and a test set with a 1:1 ratio. Univariate Cox regression and least absolute shrinkage and selection operator (LASSO) analyses were conducted to establish an 11 multilncRNA signature in the three sets. The signature divided LSCC patients into the low-risk and the high-risk groups. Kaplan–Meier analysis and receiver operating characteristic (ROC) indicated that the prognostic signature had a promising predictive capability for LSCC patients. Besides, the association of microenvironment and immunotherapy response with signature was also analyzed. Moreover, 28 potential compounds targeting signature were screened as possible drugs to treat LSCC. Finally, a nomogram model was constructed to offer the quantitative prediction and net benefit for the prognosis of LSCC patients. In conclusion, the 11 pyroptosis-related lncRNAs and their signature may be promising prognostic factors and therapeutic targets for patients with LSCC.

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“…Meanwhile, specific studies were carried out to discover the correlation between the ADCY9 gene and LUAD. It was reported that ADCY9 might be associated with the estrogen signaling pathway in LUAD, which may improve the prognosis of LUAD patients ( 46 ). Further, research exhibited that the Phospholipase C Signaling network, including mutated genes like ADCY9 , ADCY2 , and GNB5 , may indicate the facilitation of lung metastasis from colon cancer ( 47 ).…”

Section: Discussionmentioning

confidence: 99%

ADCY9 functions as a novel cancer suppressor gene in lung adenocarcinoma

Tang¹,

Wang²,

Zhang³

et al. 2023

J Thorac Dis

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Background: The process of lucubrating into lung adenocarcinoma (LUAD) is of profound clinical and practical significance in improving the prognosis of LUAD patients. Multiple biomarkers are reportedly involved in the proliferation or metastasis of adenocarcinoma. However, whether the ADCY9 gene influences the development of LUAD remains unknown. Therefore, we aimed to elucidate the relationship between the expression of ADCY9 and the proliferation and migration of LUAD.Methods: The ADCY9 gene was filtered via a survival analysis of LUAD acquired from the Gene Expression Omnibus (GEO). Then, we conducted a validation analysis and ADCY9-microRNA, microRNA-lncRNA, and ADCY9-lncRNA targeting relationship analysis through the data obtained from The Cancer Genome Atlas (TCGA) dataset. The survival curve, correlation, and prognostic analysis were implemented through bioinformatics methods. Both protein and mRNA expression levels of LUAD cell lines and LUAD patient samples (80 pairs) were detected using western blot assays and quantitative real-time polymerase chain reaction (qRT-PCR). An immunohistochemistry assay was performed to display the correlation between the expression level of the ADCY9 gene and prognosis in LUAD patients (2012-2013; n=115).Overexpression of cell lines SPCA1 and A549 were used for a series of cell function assays. Results:Compared with the expression level in adjacent normal tissues, ADCY9 expression was downregulated in LUAD tissues. Based on the result of the survival curve analysis, high expression of ADCY9 may lead to a better prognosis and may be seen as an independent predictor for LUAD patients. High expression of ADCY9-related microRNA hsa-miR-7-5p may lead to a worse prognosis, and high expression of hsa-miR-7-5p-related lncRNAs may lead to the opposite effects. Overexpression of ADCY9 restrained the proliferation, invasion, and migration abilities of SPCA1, A549 cells. Conclusions:Results indicate that the ADCY9 gene acts as a tumor suppressor to restrain the proliferation, migration, and invasion in LUAD and can lead to a better survival or prognosis in LUAD patients.

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Transcriptome Based Estrogen Related Genes Biomarkers for Diagnosis and Prognosis in Non-small Cell Lung Cancer

Cited by 10 publications

References 93 publications

Penetrating Exploration of Prognostic Correlations of the FKBP Gene Family with Lung Adenocarcinoma

Penetrating Exploration of Prognostic Correlations of the FKBP Gene Family with Lung Adenocarcinoma

Identification of pyroptosis-related long non-coding RNAs with prognosis and therapy in lung squamous cell carcinoma

ADCY9 functions as a novel cancer suppressor gene in lung adenocarcinoma

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