Transcriptome analysis reveals hepatotoxicity in zebrafish induced by cyhalofop‑butyl

A study to assess the health effects of an anticancer drug (cyclophosphamide) in zebrafish (Danio rerio): eco-toxicity of emerging contaminants

“…Environmental contaminants (including pharmaceuticals) could bind covalently with the tissue protein during metabolism, which could cause serious alterations in protein levels. 64,65 Cell damage or death mediated by drug toxicity could also decrease the protein levels in sh. 66 CP also acts on tissue protein and affects tissue barrier integrity.…”

Frontier of toxicology studies in zebrafish model

“…The liver is a major site of vertebrate material metabolism, and the zebrafish liver contains enzymes capable of metabolizing multiple endogenous and exogenous compounds similar to the human liver. Because some drugs or chemicals can cause liver damage in zebrafish, including the occurrence of vacuolization in the liver (Duan et al, 2022; Hu et al, 2022; Huang, Liu, et al, 2022; Wang, Huang, Liu, et al, 2022), liver size changes and liver steatosis (Lu, Yang, Zhu, et al, 2022), apoptosis and necrotic (Chen, Wang, et al, 2022; Siqueira et al, 2022), liver inflammation, dysregulation of lipid metabolism and glycolysis in the liver (Li et al, 2022), and hepatic lipid peroxidation (Song et al, 2022). See Table 4 for the details.…”