Transcriptome analysis reveals dialogues between human trophectoderm and endometrial cells during the implantation period

Haouzi, D.; Déchaud, H.; Assou, Saïd; Monzo, C.; Vos, John De; Hamamah, S.

doi:10.1093/humrep/der075

Cited by 94 publications

(64 citation statements)

References 70 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This chemotactic and invasive migration of endometrial stromal cells is triggered by signals emanating from the trophoblast, especially platelet-derived growth factor-AA (PDGF-AA) [36,[38][39][40]. Transcriptome analysis of trophectoderm cells from human blastocysts and matched endometrial biopsies confirmed that secretion of embryoderived PDGF-AA occurs in tandem with increased expression of its receptor, PDGF-Ra, in endometrial cells [41]. Other local growth factors that may serve to fine-tune directed and nondirected migration of decidual cells at the implantation site include PDGF-BB and HB-EGF [39].…”

Section: Embryo Selection: the Role Of Decidual Mi-grationmentioning

confidence: 99%

The Human Endometrium as a Sensor of Embryo Quality1

Macklon

Brosens

2014

Biology of Reproduction

230

171

View full text Add to dashboard Cite

Human reproduction is characterized by a high degree of embryo wastage, which is largely ascribed to a high prevalence of embryo aneuploidy. It is proposed that maternal strategies have evolved that prevent inappropriate investment in invasive, but poorly viable embryos. Key to this is the emerging concept of the endometrium as biosensor, first identified in human in vitro embryo/decidualized stromal cell coculture systems and recently confirmed in an in vivo mouse model. In this review, the growing supporting experimental evidence for the biosensor component of decidualized endometrium is outlined, and recent insights into the nature of the embryo-derived signal detected by the endometrium and the biological processes by which this signal is thought to be converted into a go or no-go endometrial response are described. Finally, the clinical implications of this new paradigm of the choosy uterus are addressed.

show abstract

Section: Embryo Selection: the Role Of Decidual Mi-grationmentioning

confidence: 99%

The Human Endometrium as a Sensor of Embryo Quality1

Macklon

Brosens

2014

Biology of Reproduction

230

171

View full text Add to dashboard Cite

show abstract

“…There was a lack of consensus on the results obtained, which was likely caused by the variability in some of the parameters such as samples taken from the same or different patients, the decision to use a pool of samples or not, the day of the cycle on which samples were taken, or the type of data analysis undertaken (Horcajadas et al 2004a,b;Giudice 2006;Simmen and Simmen 2006;Haouzi et al 2011).…”

Section: Transcriptomics Of Endometrial Receptivitymentioning

confidence: 99%

Human Endometrial Transcriptomics: Implications for Embryonic Implantation

Gómez

Ruiz-Alonso

Miravet

et al. 2015

Cold Spring Harb Perspect Med

View full text Add to dashboard Cite

Human endometrium has been extensively investigated in the search for markers capable of predicting its receptive status. The completion of the Human Genome Project has triggered a rapid development of new fields in molecular biology, the "transcriptomics" being a major turning point in the knowledge acquisition of endometrial receptivity. Based on this, a customized Endometrial Receptivity Array (ERA) has been developed, which is capable of identifying the genomic signature of receptivity. This diagnostic tool showed that the window of implantation (WOI) is displaced in one out of four patients with implantation failure, allowing the identification of their personalized WOI. This strategy allows performing a personalized embryo transfer ( pET) on the day in which the endometrium is receptive. The combination of a systems biology approach and next-generation sequencing will overcome the limitations of microarrays, and will, in the future, allow elucidation of the mechanisms involved in embryo implantation.T he endometrium, which lines the inside of the uterine cavity, undergoes cyclic changes that are regulated by ovarian steroids. It can be subdivided into the basal layer that is responsible for its regenerative capacity, and the functional layer that undergoes proliferation, secretion, and tissue degeneration every month from menarche to menopause. Its aim is to prepare the optimal moment for embryonic implantation known as the window of implantation (WOI).The endometrial cycle comprises the menstrual, proliferative, and secretory phases. The proliferative phase, which corresponds to the ovarian follicular phase and increased production of estrogens, lasts until ovulation occurs. During this stage, the increasing estrogen levels cause the proliferation of the stromal cells as well as the elongation of the spiral arteries. After ovulation, with the appearance of progesterone secreted by the granulosa-luteal cells, the secretory phase begins. If implantation does not occur, the secretory phase ends, and the corpus luteum degenerates. Menstruation occurs owing to the drop of estrogen and progesterone, which resets the endometrium until pregnancy

show abstract

“…Compared to the control placenta, several growth, angiogenic, cytokines, and immune factors in the affected placenta were upregulated in human trophoblasts, whereas some of the corresponding receptors and antagonists were overexpressed in the receptive endometrium. Failure in the pregnancy maintenance due to insufficient trophoblast invasion into the decidua may compromise fetal development, resulting in diseases of pregnancy such as recurrent pregnancy loss, intrauterine growth restriction, and preeclampsia (Haouzi et al 2011). No studies have examined the ''tug-of-war'' competition effect of paternal (e.g., trophoblasts and fetus) versus maternal (decidua) genetic states on the development of preeclampsia.…”

Section: Preeclampsia Susceptibility Genesmentioning

confidence: 99%

The Impact of Maternal-Fetal Genetic Conflict Situations on the Pathogenesis of Preeclampsia

Kobayashi

2015

Biochem Genet

View full text Add to dashboard Cite

Preeclampsia leads to maternal and perinatal morbidity and mortality. The literature in English was reviewed to summarize recent advances in understanding the global gene expression changes in the pathogenesis of preeclampsia. We identified at least eight consistently enriched categories, relating to pregnancy maintenance, metabolism, oxidative stress, cell cycle regulation, implantation, decidualization, immune modulation, and vascular function. Expression profiling in preeclampsia placenta and normal placenta revealed 140 transcripts that were significantly differentially expressed, 30 (21.4%) of which were evolved for the protection of the mother, approximately three times less than the number of genes evolved for the benefit of the fetus [110 genes (78.6%)] in preeclampsia placenta versus normal placenta. The genome-wide analysis emphasizes the dysfunctional decidualization as the main mechanism involved in the development of preeclampsia. These genetic signaling events may occur from an imbalance in the maternal-fetal genetic response in the affected placenta. This is to our knowledge the first report on the pathogenesis of preeclampsia, in which preeclampsia may occur as a genetic consequence of maternal-fetal conflict situations during the early decidualization process.

show abstract

Transcriptome analysis reveals dialogues between human trophectoderm and endometrial cells during the implantation period

Cited by 94 publications

References 70 publications

The Human Endometrium as a Sensor of Embryo Quality1

The Human Endometrium as a Sensor of Embryo Quality1

Human Endometrial Transcriptomics: Implications for Embryonic Implantation

The Impact of Maternal-Fetal Genetic Conflict Situations on the Pathogenesis of Preeclampsia

Contact Info

Product

Resources

About