Abstract:Background: Despite remarkable progress in treatment, patient management and increased survival rate, childhood acute lymphoblastic leukemia (ALL) remains a major public health problem. Traditionally white blood cell count (WBC) at diagnosis has been used as a prognostic marker. However, the molecular mechanisms and biological pathways modulating WBC have not been characterized. Here, we investigated whether genomic alterations in childhood ALL patients diagnosed with high (HWBC) and patients diagnosed with lo… Show more
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