Transcriptome Analysis of Adrenocortical Cells in Health and Disease

Ishii, Tomohiro

doi:10.1016/b978-0-12-408134-5.00011-1

Cited by 4 publications

(2 citation statements)

References 50 publications

(41 reference statements)

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“…Transcriptomic analysis typically aims for the differential identification of genes expressed in different conditions, resulting in a new understanding of the genes or pathways linked to these conditions. It requires an effective statistical tool with a multi-compared test to explain global changes in the expression of thousands of genes [42]. Several techniques, including microarray screening and RNA sequencing techniques, have been developed to analyze the gene expression.…”

Section: Transcriptomic Alterations In Alzheimer's Diseasementioning

confidence: 99%

Effect of Vitamin E on Transcriptomic Alterations in Alzheimer’s Disease

Ekeuku

Murshid

Shukri

et al. 2023

IJMS

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Research into ageing is focused on understanding why some people can maintain cognitive ability and others lose autonomy, affecting their quality of life. Studies have revealed that age-related neurodegenerative disorders like Alzheimer’s disease (AD) are now major causes of death among the elderly, surpassing malignancy. This review examines the effects of vitamin E on transcriptomic changes in ageing and neurodegenerative diseases, using AD as an example, and how different transcriptome profiling techniques can shape the results. Despite mixed results from transcriptomic studies on AD patients’ brains, we think advanced technologies could offer a more detailed and accurate tool for such analysis. Research has also demonstrated the role of antioxidant modifiers in preventing AD. This review will explore the key findings regarding AD and its modulation by vitamin E, emphasizing the shift in its epidemiology during the ageing process.

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Section: Transcriptomic Alterations In Alzheimer's Diseasementioning

confidence: 99%

Effect of Vitamin E on Transcriptomic Alterations in Alzheimer’s Disease

Ekeuku

Murshid

Shukri

et al. 2023

IJMS

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“…Komponen utama dari respon cekaman adalah sinyal cekaman, sinyal tranduksi, regulator transkripsi, gen target, dan respon cekaman, termasuk perubahan morfologi, biokimia, dan fisiologis (Bhargava & Sawant 2012;Pastori, 2002). Kemajuan studi transkriptomik telah dilaporkan pada beberapa studi dalam memecahkan masalah adaptasi tanaman, bertujuan untuk mengidentifikasi gen secara menyeluruh dan mengetahui pola ekspresi secara berbeda dikaitkan dengan adanya kondisi perlakuan dan lingkungan yang berbeda (Ishii, 2014).…”

Section: Abstrakunclassified

DIFFERENTIALLY EXPRESSED GENES(DEGS) Dryobalanops aromaticaYANG DITUMBUHKAN PADA MEDIA GAMBUT DAN TANAH MINERAL

Kusuma

Dwiyanti²,

Matra³

2021

JPTH

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Dryobalanops aromaticais a highly economic value resin-producing tree. The resin has been known as an essensialsinternational trade commodity that is widely used in the perfume, cosmetic, medicine, and other non wood industries. In its natural habitats, this species has been found to grow well onbothpeatland and mineral soilsthat has raised a question on the molecular mechanism for adaptation. However, the information regarding adaptive genes in Indonesian native trees to abiotic stress is still very limited. This research was conducted to analyse the differentially expressed genes (DEGs) that can elucidate the role of several up-regulated and down-regulated genes of D. aromaticagrown inpeat media and mineral soil. DEGanalysis was carried out using R software, Bioconductor package 'edgeR'. Using the Benjamini and Hochberg approach to control FDR (FDR 0,05), with a Log₂FC 2 and p-value of 0,05, it showed 320 contigs that were up-regulated and 439 contigs were down-regulated, while 58129 contigs were not significantly expressed. Furthermore, this study also presents an overview of the genes involved in different pathways, such as photosynthesis, glycolysis, sucrose and strarch metabolism, hormone-related genes, nitrogen metabolism, reactive oxygen species and transcription factor. This information will be useful in understanding D. aromaticamolecular responses to stress condition that may be of use for selecting genotypes in the breeding programs or peatlands restoration

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Omics approaches for elucidating molecular mechanisms of microbial bioremediation

Rawat

Rangarajan

2019

Smart Bioremediation Technologies

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Transcriptome Analysis of Adrenocortical Cells in Health and Disease

Cited by 4 publications

References 50 publications

Effect of Vitamin E on Transcriptomic Alterations in Alzheimer’s Disease

Effect of Vitamin E on Transcriptomic Alterations in Alzheimer’s Disease

DIFFERENTIALLY EXPRESSED GENES(DEGS) Dryobalanops aromaticaYANG DITUMBUHKAN PADA MEDIA GAMBUT DAN TANAH MINERAL

Omics approaches for elucidating molecular mechanisms of microbial bioremediation

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