Transcriptome Analysis and Single-Cell Sequencing Analysis Constructed the Metastasis-Related Signature in Melanoma and Identified CD74 as a Novel Biomarker
Abstract:A prevalent skin cancer with a dismal prognosis before it spreads, cutaneous melanoma is challenging to cure. We downloaded melanoma data from the TCGA database, and the patients there were split into two groups: one for training and one for validation. After that, tumor metastatic genes in melanoma were evaluated using univariate Cox regression, LASSO regression, and multivariate Cox regression. A predictive model linked to melanoma metastasis genes was then created. To categorize melanoma patients, the model… Show more
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