Transcriptional Targeting of Dendritic Cells Using an Optimized Human Fascin1 Gene Promoter
Yanira Zeyn,
Dominika Hobernik,
Ulrich Wilk
et al.
Abstract:Deeper knowledge about the role of the tumor microenvironment (TME) in cancer development and progression has resulted in new strategies such as gene-based cancer immunotherapy. Whereas some approaches focus on the expression of tumoricidal genes within the TME, DNA-based vaccines are intended to be expressed in antigen-presenting cells (e.g., dendritic cells, DCs) in secondary lymphoid organs, which in turn induce anti-tumor T cell responses. Besides effective delivery systems and the requirement of appropria… Show more
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