Transcriptional rewiring of an evolutionarily conserved circadian clock
Alejandra Goity,
Andrey Dovzhenok,
Sookkyung Lim
et al.
Abstract:Circadian clocks temporally coordinate daily organismal biology over the 24-h cycle. Their molecular design, preserved between fungi and animals, is based on a core-oscillator composed of a one-step transcriptional-translational-negative-feedback-loop (TTFL). To test whether this evolutionarily conserved TTFL architecture is the only plausible way for achieving a functional circadian clock, we adopted a transcriptional rewiring approach, artificially co-opting regulators of the circadian output pathways into t… Show more
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