Transcriptional remodeling by OTX2 directs specification and patterning of mammalian definitive endoderm
Ly-sha Ee,
Dani Medina-Cano,
Christopher Uyehara
et al.
Abstract:The molecular mechanisms that drive essential developmental patterning events in the mammalian embryo remain poorly understood. To generate a conceptual framework for gene regulatory processes during germ layer specification, we analyzed transcription factor (TF) expression kinetics around gastrulation and during in vitro differentiation. This approach identified Otx2 as a candidate regulator of definitive endoderm (DE), the precursor of all gut-derived tissues. Analysis of multipurpose degron alleles in gastr… Show more
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