Transcriptional regulation of the Ras‐related protein TC21/R‐Ras2 in endothelial cells

The Ras-like protein R-Ras2/TC21 is important for proper mammary gland development

“…This differential regulation is not unheard off in the case of the R-Ras subfamily. Indeed, other reports showed that the expression of the RRas2 gene can change in different cell types during physiological and/or pathological conditions (Drivas et al , 1990; Kozian and Augustin, 1997; Larkin et al , 2004; Zhu et al , 2005; Rokavec et al , 2008). Similarly, the down-regulation of the RRas1 gene has been described in vascular smooth muscle cells during both neointima formation and tumor-induced neoangiogenesis (Komatsu and Ruoslahti, 2005).…”