Transcriptional regulation of HIV-1 host factor COMMD1 by the Sp family

Kudo, Eriko; Taura, Manabu; Suico, Mary Ann; Goto, Hiroki; Kai, Hirofumi; Okada, Seiji

doi:10.3892/ijmm.2018.3386

Cited by 3 publications

(3 citation statements)

References 28 publications

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“…Besides hCtr1, Sp1 is also known to regulate ATP7A through promoter binding [97]. Moreover, Sp1 also transcriptionally regulates COMMD1 by binding to its promoter [98]. Although cDDP does not directly act upon Sp1, or very weakly at best, it was found that cDDP enhances Sp1-DNA binding in vitro [94], consistent with the previous observations that cDDP induces Sp1 and hCtr1 expression [99].…”

Section: The Cu-sp1-hctr1 Inter-regulatory Loop In Humanssupporting

confidence: 87%

Targeting the Copper Transport System to Improve Treatment Efficacies of Platinum-Containing Drugs in Cancer Chemotherapy

et al. 2021

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The platinum (Pt)-containing antitumor drugs including cisplatin (cis-diamminedichloroplatinum II, cDDP), carboplatin, and oxaliplatin, have been the mainstay of cancer chemotherapy. These drugs are effective in treating many human malignancies. The major cell-killing target of Pt drugs is DNA. Recent findings underscored the important roles of Pt drug transport system in cancer therapy. While many mechanisms have been proposed for Pt-drug transport, the high-affinity copper transporter (hCtr1), Cu chaperone (Atox1), and Cu exporters (ATP7A and ATP7B) are also involved in cDDP transport, highlighting Cu homeostasis regulation in Pt-based cancer therapy. It was demonstrated that by reducing cellular Cu bioavailable levels by Cu chelators, hCtr1 is transcriptionally upregulated by transcription factor Sp1, which binds the promoters of Sp1 and hCtr1. In contrast, elevated Cu poisons Sp1, resulting in suppression of hCtr1 and Sp1, constituting the Cu-Sp1-hCtr1 mutually regulatory loop. Clinical investigations using copper chelator (trientine) in carboplatin treatment have been conducted for overcoming Pt drug resistance due in part to defective transport. While results are encouraging, future development may include targeting multiple steps in Cu transport system for improving the efficacies of Pt-based cancer chemotherapy. The focus of this review is to delineate the mechanistic interrelationships between Cu homeostasis regulation and antitumor efficacy of Pt drugs.

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Section: The Cu-sp1-hctr1 Inter-regulatory Loop In Humanssupporting

confidence: 87%

Targeting the Copper Transport System to Improve Treatment Efficacies of Platinum-Containing Drugs in Cancer Chemotherapy

et al. 2021

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“…This review focuses on the biological roles of the COMMD protein family and the particularity of COMMD1, and involves as far as possible the research results about other members of the COMMD protein family. Given the functional diversity of COMMD proteins, the COMMD protein family is implicated in numerous disease processes, such as hepatitis ( 8 , 9 ), myocardial ischemia ( 10 – 12 ), cerebral ischemia ( 13 ), HIV infection ( 14 , 15 ), and malignancies ( 4 ). COMMD1 deficiency induces or worsens hepatitis in mouse and dogs, and the mechanism might involve an increase in intracellular hepatic copper and hepatic lipid accumulation ( 8 , 9 ).…”

Section: Introductionmentioning

confidence: 99%

COMMD proteins function and their regulating roles in tumors

et al. 2023

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The COMMD proteins are a highly conserved protein family with ten members that play a crucial role in a variety of biological activities, including copper metabolism, endosomal sorting, ion transport, and other processes. Recent research have demonstrated that the COMMD proteins are closely associated with a wide range of disorders, such as hepatitis, myocardial ischemia, cerebral ischemia, HIV infection, and cancer. Among these, the role of COMMD proteins in tumors has been thoroughly explored; they promote or inhibit cancers such as lung cancer, liver cancer, gastric cancer, and prostate cancer. COMMD proteins can influence tumor proliferation, invasion, metastasis, and tumor angiogenesis, which are strongly related to the prognosis of tumors and are possible therapeutic targets for treating tumors. In terms of molecular mechanism, COMMD proteins in tumor cells regulate the oncogenes of NF-κB, HIF, c-MYC, and others, and are related to signaling pathways including apoptosis, autophagy, and ferroptosis. For the clinical diagnosis and therapy of malignancies, additional research into the involvement of COMMD proteins in cancer is beneficial.

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“…Host proteins are similarly recruited to viral promoter regions for the analogous replicative processes. For example, HIV-1 recruits Sp1 to its COMMD1 (COMM domain-containing protein 1) promoter region to regulate transcription [ 21 ]; and in human papillomavirus (HPV), Sp1, AP1, and NF1 are recruited to early promoters to initiate transcription [ 22 , 23 , 24 ]. Thus, for effective infection, those regions that interact with the host proteins would also need to be highly conserved.…”

Section: Introductionmentioning

confidence: 99%

Comprehensive Analysis of Hepatitis B Virus Promoter Region Mutations

Meier-Stephenson

Bremner

Dalton

et al. 2018

Viruses

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Over 250 million people are infected chronically with hepatitis B virus (HBV), the leading cause of liver cancer worldwide. HBV persists, due, in part, to its compact, stable minichromosome, the covalently-closed, circular DNA (cccDNA), which resides in the hepatocytes’ nuclei. Current therapies target downstream replication products, however, a true virological cure will require targeting the cccDNA. Finding targets on such a small, compact genome is challenging. For HBV, to remain replication-competent, it needs to maintain nucleotide fidelity in key regions, such as the promoter regions, to ensure that it can continue to utilize the necessary host proteins. HBVdb (HBV database) is a repository of HBV sequences spanning all genotypes (A–H) amplified from clinical samples, and hence implying an extensive collection of replication-competent viruses. Here, we analyzed the HBV sequences from HBVdb using bioinformatics tools to comprehensively assess the HBV core and X promoter regions amongst the nearly 70,000 HBV sequences for highly-conserved nucleotides and variant frequencies. Notably, there is a high degree of nucleotide conservation within specific segments of these promoter regions highlighting their importance in potential host protein-viral interactions and thus the virus’ viability. Such findings may have key implications for designing antivirals to target these areas.

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Transcriptional regulation of HIV-1 host factor COMMD1 by the Sp family

Cited by 3 publications

References 28 publications

Targeting the Copper Transport System to Improve Treatment Efficacies of Platinum-Containing Drugs in Cancer Chemotherapy

Targeting the Copper Transport System to Improve Treatment Efficacies of Platinum-Containing Drugs in Cancer Chemotherapy

COMMD proteins function and their regulating roles in tumors

Comprehensive Analysis of Hepatitis B Virus Promoter Region Mutations

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