Transcriptional regulation of fosl-1 by licorice in rat Clone 9 cells

Leung, Yuet-Kin; Ng, Tzi Bun; Ho, John W.

doi:10.1016/j.lfs.2003.05.003

Cited by 8 publications

(3 citation statements)

References 23 publications

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“…It is suggested that glycyrrhizin has a preventive effect on the development of hepatocellular carcinoma (HCC) in patients with HCV-associated chronic hepatitis (Arase et al, 1997;Miyakawa and Iino, 2001). Licorice has been reported to have a direct hepatoprotective effect (Luper, 1999;Leung et al, 2003). Glycyrrhizin, its major component, is often used to treat patients with chronic liver damage who do not receive or respond to interferon (IFN) therapy (Okuno et al, 2001).…”

Section: Antiviral and Hepatoprotective Effectsmentioning

confidence: 99%

Review of Pharmacological Effects of Glycyrrhiza sp. and its Bioactive Compounds

Nassiri‐Asl

Hosseinzadeh

2008

Phytotherapy Research

1,001

689

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The roots and rhizomes of licorice (Glycyrrhiza) species have long been used worldwide as a herbal medicine and natural sweetener. Licorice root is a traditional medicine used mainly for the treatment of peptic ulcer, hepatitis C, and pulmonary and skin diseases, although clinical and experimental studies suggest that it has several other useful pharmacological properties such as antiinflammatory, antiviral, antimicrobial, antioxidative, anticancer activities, immunomodulatory, hepatoprotective and cardioprotective effects. A large number of components have been isolated from licorice, including triterpene saponins, flavonoids, isoflavonoids and chalcones, with glycyrrhizic acid normally being considered to be the main biologically active component. This review summarizes the phytochemical, pharmacological and pharmacokinetics data, together with the clinical and adverse effects of licorice and its bioactive components.

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Section: Antiviral and Hepatoprotective Effectsmentioning

confidence: 99%

Review of Pharmacological Effects of Glycyrrhiza sp. and its Bioactive Compounds

Nassiri‐Asl

Hosseinzadeh

2008

Phytotherapy Research

1,001

689

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“…8) showed inductive effects on the gene expression associated with apoptotic processes in Clone 9 cells [55][56]. These genes include GST-pi, DT-diaphorase, PAI-1, fosl-1 and uPAR.…”

Section: Introductionmentioning

confidence: 99%

Activation of p53 by Specific Agents in Potential Cancer Therapy

Song²,

Leung³

2005

CMCACA

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Tumor suppressor genes can promote p53-mediated apoptosis. Apoptosis is an important protective mechanism for normal cell growth. Aberrant regulation of p53 expression is linked to cancer development. The loss of function of p53 often results in tumorigenicity. It is reported that the high incidence of tumors in p53-deficient animals is highly attributed to p53-induced apoptosis. Malignancies that retain the wild-type p53 gene are associated with the biologic activity of p53 function. Most cancer cells show defects in p53 or inhibition in the associated pathways. A lot of effort has been focused on reactivating mutant p53, or recombinant technique to incorporate p53 in cells. Regulation of p53 has been described at both transcription and translation level. Activation of the p53 pathway appears to be an effective approach in inhibiting tumor development. In the present study, we have reviewed the recent developments of specific compounds that can regulate p53 expression and its function in cell growth and development. Integral to this is the function of other proteins that affect p53 activity.

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“…GL has been proposed to induce apoptosis in the hepatoma cell line HLE or act on an activator protein‐1 (AP‐1)‐responsive element to inhibit cellular transformation (98, 99). Global genomic analysis of licorice‐treated hepatocytes revealed over‐expressions of genes relating to biotransformation phase II enzymes (DT‐diaphorase and glutathione S ‐transferase Pi subunit) and cell motility (urokinase‐type plasminogen activator surface receptor and plasminogen activator inhibitor‐1) (100).…”

Section: Current Uses Of Traditional Chinese Medicine In Treating Hccmentioning

confidence: 99%

Traditional Chinese herbal medicines for treatment of liver fibrosis and cancer: from laboratory discovery to clinical evaluation

Luk

Wang

Liu

et al. 2007

Liver International

117

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Transcriptional regulation of fosl-1 by licorice in rat Clone 9 cells

Cited by 8 publications

References 23 publications

Review of Pharmacological Effects of Glycyrrhiza sp. and its Bioactive Compounds

Review of Pharmacological Effects of Glycyrrhiza sp. and its Bioactive Compounds

Activation of p53 by Specific Agents in Potential Cancer Therapy

Traditional Chinese herbal medicines for treatment of liver fibrosis and cancer: from laboratory discovery to clinical evaluation

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