Transcriptional regulation of ferritin heavy chain messenger RNA expression by thyroid hormone

Iwasa, Yasushi; Aida, Kaoru; Yokomori, Norihiko; Inoue, Masaharu; Onaya, Toshimasa

doi:10.1016/0006-291x(90)90662-7

Cited by 19 publications

(14 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…102 Short fragments of the rat 5Ј flanking region (up to 400 bp) but not longer fragments were responsive to dibutyryl-cAMP and thyrotropin in murine 3T3 cells and FRTL5 thyroid cells. 103,104 Nuclear run-on assays confirmed the transcriptional effect of thyrotropin on ferritin H. 105 The cAMP-dependent induction of ferritin was inhibited by ras in a rat thyroid cell line. 106 Collectively, these experiments demonstrated that thyrotropin increased ferritin H transcription, probably by elevating cAMP.…”

Section: Ferritin Regulation By Cytokines and Inflammationmentioning

confidence: 85%

Regulation of ferritin genes and protein

Torti

2002

Blood

985

819

View full text Add to dashboard Cite

Section: Ferritin Regulation By Cytokines and Inflammationmentioning

confidence: 85%

Regulation of ferritin genes and protein

Torti

2002

Blood

985

819

View full text Add to dashboard Cite

“…FTH1 is known to be regulated by a large number of factors including positive regulation by thyroid stimulating hormone, NFjb, insulin, chemokines, immunoglobulins and interleukins (Iwasa et al 1990;Iwasaki et al 2006;Yokomori et al 1991;Anders et al 2003;McLeish et al 1982;Chen et al 2005). The expression of FTH1 is known to affect iron homeostasis, cell proliferation and lipid peroxidation (Goralska et al 1998;McLeish et al 1980;Cozzi et al 1990).…”

Section: Averaged Expressionmentioning

confidence: 91%

Microarray analysis of differential utilization of plant-based diets by rainbow trout

et al. 2011

View full text Add to dashboard Cite

Microarray analysis was conducted using liver samples from two families of rainbow trout that differed in their growth responses when compared between individuals fed a fishmeal or plant protein-based diet. Differential expression relating to dietary utilization between the two families found significant changes in expression of 33 expressed sequence tags (ESTs). Eight of the differentially expressed ESTs had identified mammalian homologs that had been previously researched with identified cellular interactions and functions. Utilizing pathway analysis software to analyze sequences annotated with known mammalian genes, we were able to map gene pathways and process interactions. From this information, we were able to infer that the metabolic changes associated with utilization of plant protein versus fishmeal were associated with differential regulation of genes related to cell oxidative stress, proliferation, growth and survival. Furthermore, we inferred from the changes we observed in immune response gene expression that ingestion of this plantbased diet upregulated the expression of genes involved in immunoregulatory processes.

show abstract

“…Mechanism of cAMP-PKA Stimulation of Ferritin Gene Transcription-H ferritin mRNA levels and transcription of the gene in vivo are stimulated by cAMP (3,10,21,22). The identification of the primary target sequences responsive to cAMP signaling in the H ferritin promoter has not been carried out extensively.…”

Section: Discussionmentioning

confidence: 99%

A Common Mechanism Underlying the E1A Repression and the cAMP Stimulation of the H Ferritin Transcription

Bevilacqua

Faniello

Quaresima

et al. 1997

Journal of Biological Chemistry

View full text Add to dashboard Cite

Transcription of the H ferritin gene in vivo is stimulated by cAMP and repressed by the E1A oncoprotein. We report here the identification of the cis-element in the human promoter responsive to both cAMP-and E1A-mediated signals. This promoter region is included between positions ؊62 to ؊45 and binds a approximate 120-kDa transcription factor called Bbf. Bbf forms a complex in vivo with the coactivator molecules p300 and CBP. Recombinant E1A protein reduces the formation of these complexes. In vivo overexpression of p300 in HeLa cells reverses the E1A-mediated inhibition of the ferritin promoter transcription driven by Bbf. These data suggest the existence of a common mechanism for the cAMP activation and the E1A-mediated repression of H ferritin transcription.

show abstract

Transcriptional regulation of ferritin heavy chain messenger RNA expression by thyroid hormone

Cited by 19 publications

References 26 publications

Regulation of ferritin genes and protein

Regulation of ferritin genes and protein

Microarray analysis of differential utilization of plant-based diets by rainbow trout

A Common Mechanism Underlying the E1A Repression and the cAMP Stimulation of the H Ferritin Transcription

Contact Info

Product

Resources

About