Transcriptional Regulation of Energy Metabolism in Cancer Cells

Rodrı́guez-Enrı́quez, Sara; Marín‐Hernández, Álvaro; Gallardo‐Pérez, Juan Carlos; Pacheco-Velázquez, Silvia Cecilia; Belmont-Díaz, Javier A.; Robledo‐Cadena, Diana Xochiquetzal; Vargas-Navarro, Jorge Luis; Peña, Norma Angélica Corona de la; Saavedra, Emma; Moreno‐Sánchez, Rafael

doi:10.3390/cells8101225

Cited by 51 publications

(31 citation statements)

References 188 publications

(165 reference statements)

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“…Glycolysis is characterized by an increased rate of glucose uptake and its glycolytic conversion to lactate, even under oxygen-rich conditions ( 55 ). There are several pathways and transcriptional regulators involved in the regulation of metabolic reprogramming, such as PI3K/AKT pathway and HIF-1 ( 58 , 59 ). The PI3K/AKT pathway can regulate several aspects of this metabolic program ( 58 ).…”

Section: Reprogrammed Energy Metabolism and Gcmentioning

confidence: 99%

“…HIF-1 may also be triggered by the accumulation of TCA substrates ( 62 ), while its degradation is regulated by O 2 -dependent prolyl hydroxylation (PHs) ( 61 ). HIF-1α maintains its stability by avoiding the hydroxylation of PHs in cancer cells, since PHs can be inhibited by the increased levels of cytosolic pyruvate, lactate, succinate, fumarate and ROS ( 59 ). Most genes encoding glycolytic enzymes and transporters are the targets of HIF-1α, and its overexpression in cancer cells is associated with increased levels of glycolytic proteins ( 63 ).…”

Section: Reprogrammed Energy Metabolism and Gcmentioning

confidence: 99%

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Potential role of mitochondria in gastric cancer detection: Fission and glycolysis (Review)

Yang

2021

Oncol Lett

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Gastric cancer (GC) is characterized by high morbidity and mortality rates worldwide. Helicobacter pylori infection, high salt intake, smoking, alcohol, low fiber intake, family history of GC, obesity and precancerous lesions, including chronic atrophic gastritis and intestinal metaplasia, are considered general risk factors for GC. Image enhancement endoscopy methods, which improve the visualization of mucosal structures and vascularity, may be used for the early diagnosis of GC, such as narrow band imaging, which can reveal fine details of subtle superficial abnormalities of early gastric cancer (EGC). Mitochondria are well-known for their role in producing ATP via the tricarboxylic acid cycle. In cancer cells, the energetic metabolism can be reprogrammed as anaerobic glycolysis for energy production and anabolic growth. In addition to their dominant metabolic functions, mitochondria participate in several central signaling pathways, such as the apoptotic pathway and NLRP3 inflammasome activation. Conversely, mitochondrial dynamics, including fission/fusion and mitophagy, can also contribute to the pathogenesis of cancer. The dysfunction and dysregulation of mitochondria have been associated with several ageing and degenerative diseases, as well as cancer. The present review focuses on energy metabolism and mitochondrial dynamics, and summarizes the changes in gastric carcinogenesis, the diagnosis of EGC and indicates potential targeted treatments.

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Section: Reprogrammed Energy Metabolism and Gcmentioning

confidence: 99%

Section: Reprogrammed Energy Metabolism and Gcmentioning

confidence: 99%

Potential role of mitochondria in gastric cancer detection: Fission and glycolysis (Review)

Yang

2021

Oncol Lett

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“…Since, astrocytes are considered to be a precursors cells of astrocytoma, it might be deduce that the observed expression of PC in astrocytoma cells is maintained during the process of tumorigenic transformation of astrocytes. The cancer cells possess the capability to alter the expression and activity of PC (Phannasil et al 2015;Oppermann et al 2016), and therefore, the described presence of PC in neuroblastoma cells, in contrast to neurons, could be a consequence of changes in the gene expression underlying the metabolic transformation of cells during carcinogenesis (Rodríguez-Enríquez et al 2019) and an metabolic adaptation of neuroblastoma cells to meet their metabolic needs.…”

Section: Discussionmentioning

confidence: 99%

Expression of pyruvate carboxylase in cultured human astrocytoma, glioblastoma and neuroblastoma cells

Gondáš

Trančiková²,

Majerčíková³

et al. 2021

gpb

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Pyruvate carboxylase (PC) is an enzyme catalyzing the conversion of pyruvate to oxaloacetate, which possesses anaplerotic role in cellular metabolism. The expression of PC was confirmed in cells of several cancer types, in which it ensures several cellular functions, such as growth and division. To investigate the expression of PC in human astrocytoma, glioblastoma and neuroblastoma cells we applied the immunodetection methods. The results of the Western blot analysis and immunocytochemical detection revealed the presence of PC in human astrocytoma, glioblastoma and neuroblastoma cells. Furthermore, application of PC inhibitor, 3-chloro-1,2-dihydroxypropane (CDP), negatively impacts the viability of astrocytoma cells. The cytotoxic effect of CDP could be partially reversed by application of citrate, 2-oxoglutarate and malate in incubation media. Our results revealed that astrocytoma, glioblastoma and neuroblastoma cells are equipped with PC, which might significantly contribute by its anaplerotic activity to sustain the metabolism of cancer cells.

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“…Mechanistically, transcription can be divided into four stages: (1) The formation of the preinitiation complex, (2) transcription initiation, (3) transcription elongation, and (4) transcription termination (Figure 1). A more detailed biological overview of transcription can be found in other recent reviews (Cramer, 2019;Kujirai and Kurumizaka, 2019;Rodríguez-Enríquez et al, 2019;Babokhov et al, 2020).…”

Section: Targeting Transcriptionmentioning

confidence: 99%

Transcription and Translation Inhibitors in Cancer Treatment

et al. 2020

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Transcription and translation are fundamental cellular processes that govern the protein production of cells. These processes are generally up regulated in cancer cells, to maintain the enhanced metabolism and proliferative state of these cells. As such cancerous cells can be susceptible to transcription and translation inhibitors. There are numerous druggable proteins involved in transcription and translation which make lucrative targets for cancer drug development. In addition to proteins, recent years have shown that the "undruggable" transcription factors and RNA molecules can also be targeted to hamper the transcription or translation in cancer. In this review, we summarize the properties and function of the transcription and translation inhibitors that have been tested and developed, focusing on the advances of the last 5 years. To complement this, we also discuss some of the recent advances in targeting oncogenes tightly controlling transcription including transcription factors and KRAS. In addition to natural and synthetic compounds, we review DNA and RNA based approaches to develop cancer drugs. Finally, we conclude with the outlook to the future of the development of transcription and translation inhibitors.

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Transcriptional Regulation of Energy Metabolism in Cancer Cells

Cited by 51 publications

References 188 publications

Potential role of mitochondria in gastric cancer detection: Fission and glycolysis (Review)

Potential role of mitochondria in gastric cancer detection: Fission and glycolysis (Review)

Expression of pyruvate carboxylase in cultured human astrocytoma, glioblastoma and neuroblastoma cells

Transcription and Translation Inhibitors in Cancer Treatment

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