Transcriptional regulation of adipogenic marker genes for the improvement of intramuscular fat in Qinchuan beef cattle

Guo, Huiling; Khan, Rajwali; Raza, Sayed Haidar Abbas; Kaster, Nurgulsim; Suhail, Syed Muhammad; Rahman, Abdur; Ahmed, Ijaz; Ijaz, Asim; Ahmad, Iftikhar; Liu, Zan

doi:10.1080/10495398.2020.1837847

Cited by 15 publications

(6 citation statements)

References 156 publications

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“…Total lipid of meat is one of the main determinants of sensory and instrumental meat quality characteristics [ 30 , 31 ]. In the present study, the average intramuscular fat was 4.5 g/100g, which is within the range commonly found for Dorper × Santa Inês lambs [ 32 ].…”

Section: Discussionmentioning

confidence: 99%

Lambs supplemented with Amazonian oilseed co-products: Meat quality and fatty acid profile

de Castro,

Budel,

Rodrigues

et al. 2023

PLoS ONE

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The Amazon has a wide variety of oilseeds that generate a huge amount of co-products with potential for use in animal nutrition. The objective was to use alternative resources (oilseed cakes) in the feeding of lambs to assign a sustainable destination to this biomass, and evaluate its influence on the quality and fatty acid (FA) profile of the meat. Twenty-four lambs, male, castrated, crossbred Dorper × Santa Inês, weighing 30 ± 1.3 kg of initial body weight, were distributed in a completely randomized design in 4 treatments (diets) with six replications (animals). The control diet (Control) contained corn and soybean meal as main ingredients, which were partially replaced in the other diets by cupuassu cake diet (Cup), palm kernel cake diet (Palm) and tucuma cake diet (Tuc). The inclusion of Amazon cakes influences the lipid (P = 0.02) and protein (P < 0.01) composition of meat (longissimus lumborum); reduces cooking losses (P < 0.01); influences the colors (L, a, b), chroma, and Hue Angle (P < 0.01); promotes changes in total FA composition and FA profile (P < 0.05); reduces hypocholesterolemic FA (h) (P = 0.01), but does not influence hypercholesterolemic (H) and indices h:H, AI and TI (P > 0.05). The inclusion of oilseed cakes influences the chemical composition, physical parameters, composition and fatty acid profile of the meat, but does not influence the indicators of atherogenicity, thrombogenicity and cholesterolemia.

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Section: Discussionmentioning

confidence: 99%

Lambs supplemented with Amazonian oilseed co-products: Meat quality and fatty acid profile

de Castro,

Budel,

Rodrigues

et al. 2023

PLoS ONE

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“…The lamb quality directly affects consumers' choices [8]. Intramuscular fat (IMF) is a key factor determining meat quality, affecting meat tenderness, flavor, and juiciness [9][10][11]. Therefore, it is particularly important to search for target molecules related to IMF deposition in sheep and improve their meat quality at the molecular level.…”

Section: Introductionmentioning

confidence: 99%

Verification of Key Target Molecules for Intramuscular Fat Deposition and Screening of SNP Sites in Sheep from Small-Tail Han Sheep Breed and Its Cross with Suffolk

Fu,

Shi,

Meng

et al. 2024

IJMS

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Intramuscular fat (IMF) is vital for meat tenderness and juiciness. This study aims to explore the IMF deposition mechanism and the related molecular markers in sheep. Two populations, Small-tail Han Sheep (STH) and STH × Suffolk (SFK) F1 (SFK × STH), were used as the research object. Histological staining techniques compared the differences in the longissimus dorsi muscle among populations. A combination of transcriptome sequencing and biological information analysis screened and identified IMF-related target genes. Further, sequencing technology was employed to detect SNP loci of target genes to evaluate their potential as genetic markers. Histological staining revealed that the muscle fiber gap in the SFK × STH F1 was larger and the IMF content was higher. Transcriptome analysis revealed that PIK3R1 and PPARA were candidate genes. Histological experiments revealed that the expressions of PIK3R1 mRNA and PPARA mRNA were lower in SFK × STH F1 compared with the STH. Meanwhile, PIK3R1 and PPARA proteins were located in intramuscular adipocytes and co-located with the lipid metabolism marker molecule (FASN). SNP locus analysis revealed a mutation site in exon 7 of the PIK3R1 gene, which served as a potential genetic marker for IMF deposition. This study’s findings will provide a new direction for meat quality breeding in sheep.

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“…SREBPs regulate fatty acid production and uptake genes (Liu, Huang, et al., 2020; Siersbæk et al., 2010). The link between the C/EBP and SREBP families has gotten a lot of attention (Hongfang et al., 2022). While human transcription factors have complete curated collections, information on bovine transcription factors is lacking (de Souza et al., 2018).…”

Section: Introductionmentioning

confidence: 99%

A review of the role of transcription factors in regulating adipogenesis and lipogenesis in beef cattle

Abebe,

Wang,

et al. 2023

J Animal Breeding Genetics

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In the past few decades, genomic selection and other refined strategies have been used to increase the growth rate and lean meat production of beef cattle. Nevertheless, the fast growth rates of cattle breeds are often accompanied by a reduction in intramuscular fat (IMF) deposition, impairing meat quality. Transcription factors play vital roles in regulating adipogenesis and lipogenesis in beef cattle. Meanwhile, understanding the role of transcription factors in regulating adipogenesis and lipogenesis in beef cattle has gained significant attention to increase IMF deposition and meat quality. Therefore, the aim of this paper was to provide a comprehensive summary and valuable insight into the complex role of transcription factors in adipogenesis and lipogenesis in beef cattle. This review summarizes the contemporary studies in transcription factors in adipogenesis and lipogenesis, genome‐wide analysis of transcription factors, epigenetic regulation of transcription factors, nutritional regulation of transcription factors, metabolic signalling pathways, functional genomics methods, transcriptomic profiling of adipose tissues, transcription factors and meat quality and comparative genomics with other livestock species. In conclusion, transcription factors play a crucial role in promoting adipocyte development and fatty acid biosynthesis in beef cattle. They control adipose tissue formation and metabolism, thereby improving meat quality and maintaining metabolic balance. Understanding the processes by which these transcription factors regulate adipose tissue deposition and lipid metabolism will simplify the development of marbling or IMF composition in beef cattle.

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Transcriptional regulation of adipogenic marker genes for the improvement of intramuscular fat in Qinchuan beef cattle

Cited by 15 publications

References 156 publications

Lambs supplemented with Amazonian oilseed co-products: Meat quality and fatty acid profile

Lambs supplemented with Amazonian oilseed co-products: Meat quality and fatty acid profile

Verification of Key Target Molecules for Intramuscular Fat Deposition and Screening of SNP Sites in Sheep from Small-Tail Han Sheep Breed and Its Cross with Suffolk

A review of the role of transcription factors in regulating adipogenesis and lipogenesis in beef cattle

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