Transcriptional Profiling with a Pathway-Oriented Analysis Identifies Dysregulated Molecular Phenotypes in the Endometrium of Patients with Polycystic Ovary Syndrome

Abstract

Systemic down-regulation of various signaling pathways in PCOSE with extremely prolonged proliferative phase provides insight into the abnormal phenotypes that reflect pathophysiology of PCOS in the endometrium, possibly leading to increased risks of endometrial disorders.

Warburg-like Glycolysis and Lactate Shuttle in Mouse Decidua during Early Pregnancy

“…Additionally, patients with idiopathic infertility show decreased Glut1 expression in the endometrial stromal cells, suggesting the influence of dysfunction of endometrial stromal and decidual cells upon glucose metabolism (8,19). Patients with polycystic ovary syndrome also show disturbed glycolysis and reduced proliferation rate of endometrial stromal cells (20). Disordered glucose metabolism in human endometrium is also involved in the poor fertility of older women or of women taking oral contraceptives (18).…”

Endometrial progesterone resistance and PCOS

“…However, differential changes in gene expression in the endometrium have been shown to be associated with the onset of PCOS in women [19] with progesterone resistance [16]. One intriguing finding is that the alterations in many PR-related genes are evident in women with endometriosis and accompanying progesterone resistance [41], but there are not many genes changed in women with PCOS and accompanying progesterone resistance [16].…”

Current perspectives of insulin resistance and polycystic ovary syndrome

“…Women with PCOS are thought to have altered physiology of the endometrium, possibly leading to implantation failure, spontaneous pregnancy loss and endometrial hyperplasia and adenocarcinoma [42]. Insulin, as an important growth factor, can regulate endometrial cell growth and apoptosis.…”