Transcriptional profiling of mitochondria associated genes in prefrontal cortex of subjects with major depressive disorder

Wang, Qingzhong; Dwivedi, Yogesh K.

doi:10.1080/15622975.2016.1197423

Cited by 36 publications

(24 citation statements)

References 48 publications

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“…This topic has been reviewed in detail recently ( Petschner et al, 2018 ), so only a few examples will be mentioned here. A recent systematic assessment using mitochondrial PCR array profiling identified 16 genes that were differentially expressed in the dorsolateral prefrontal cortex of post-mortem brains from depressed patients compared to control subjects ( Wang and Dwivedi, 2017 ). The identified genes are ones known to govern oxidative stress and neuronal ATP levels, suggesting for the first time that mitochondrial genes might be altered in tissue samples from human patients.…”

Section: Geneticsmentioning

confidence: 99%

Mitochondria and Mood: Mitochondrial Dysfunction as a Key Player in the Manifestation of Depression

et al. 2018

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Human and animal studies suggest an intriguing link between mitochondrial diseases and depression. Although depression has historically been linked to alterations in monoaminergic pharmacology and adult hippocampal neurogenesis, new data increasingly implicate broader forms of dampened plasticity, including plasticity within the cell. Mitochondria are the cellular powerhouse of eukaryotic cells, and they also regulate brain function through oxidative stress and apoptosis. In this paper, we make the case that mitochondrial dysfunction could play an important role in the pathophysiology of depression. Alterations in mitochondrial functions such as oxidative phosphorylation (OXPHOS) and membrane polarity, which increase oxidative stress and apoptosis, may precede the development of depressive symptoms. However, the data in relation to antidepressant drug effects are contradictory: some studies reveal they have no effect on mitochondrial function or even potentiate dysfunction, whereas other studies show more beneficial effects. Overall, the data suggest an intriguing link between mitochondrial function and depression that warrants further investigation. Mitochondria could be targeted in the development of novel antidepressant drugs, and specific forms of mitochondrial dysfunction could be identified as biomarkers to personalize treatment and aid in early diagnosis by differentiating between disorders with overlapping symptoms.

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Section: Geneticsmentioning

confidence: 99%

Mitochondria and Mood: Mitochondrial Dysfunction as a Key Player in the Manifestation of Depression

et al. 2018

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“…Dies wird auch durch Studienergebnisse, welche auf eine maternale Vererbung von psychiatrischen Erkrankungen hinweisen verdeutlicht [18][19][20]. Unter anderem dürfte es ebenfalls bei Depressionen zu Veränderungen der Mitochondrien kommen: Beispielsweise konnte eine Studie mit 11 Patienten Veränderungen mitochondrialer Systeme im Gehirn bei PatientInnen mit Depression im Vergleich zu gesunden Kontrollen feststellen [21], während eine andere Studie mit 40 PatientInnen mit Major Depression signifikante Verminderungen der mitochondrialen DNA im Vergleich zu gesunden Kontrollen ermitteln konnte [22]. Ebenso zeigen Studien eine mitochondriale Dysfunktion bei Angsterkrankungen [23,24].…”

Section: Neuropsychologische Befundeunclassified

Die Kraftwerke der Zellen- über die Behandlung von psychiatrischen Symptomen bei Patienten mit Mitochondriopathien

Mörkl¹,

Tmava²,

Blesl³

et al. 2017

Fortschr Neurol Psychiatr

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Mitochondriopathies are pathologies of cell organelles, which are essential for the formation of adenosine triphosphate (ATP), which is responsible for cellular energy stock. When mitochondrial mutations occur, symptoms arise frequently in those organs that rely on a continuous energy supply, such as the nervous system. Although psychiatric illness is increasingly prevalent in patients with mitochondrial disease, less attention has been paid to its psychiatric presentations. We describe a case of a 21-year-old woman who presented in our outpatient department with panic attacks and depression. The patient experienced major side effects after low-dose sertraline therapy. Mitochondriopathies belong to the class of rare illnesses in psychiatry; nevertheless, they require adaptations of psychopharmacological therapy. Psychotropic drugs are potential respiratory chain inhibitors and could lead to distinct side effects.

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“…However, information regarding the precise stress-induced changes in mitochondria-associated genes in brain regions relevant for depression symptomatology, and how they relate to depression-related behavioral manifestations, is scarce. Only a few studies have investigated alterations in the transcriptional expression of mitochondria-associated genes in the brain of major depression disorder (MDD) subjects 33 , including the PFC 34 . In rodent models of chronic stress, a recent multi-omics study including genome-wide analyses identified mitochondrial-related alterations in gene expression in the bed nucleus of stria terminalis, an anxiety-related brain region 35 .…”

Section: Introductionmentioning

confidence: 99%

Mitochondrial gene signature in the prefrontal cortex for differential susceptibility to chronic stress

Weger

Alpern

Cherix

et al. 2020

Sci Rep

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Mitochondrial dysfunction was highlighted as a crucial vulnerability factor for the development of depression. However, systemic studies assessing stress-induced changes in mitochondria-associated genes in brain regions relevant to depression symptomatology remain scarce. Here, we performed a genome-wide transcriptomic study to examine mitochondrial gene expression in the prefrontal cortex (PFC) and nucleus accumbens (NAc) of mice exposed to multimodal chronic restraint stress. We identified mitochondria-associated gene pathways as most prominently affected in the PFC and with lesser significance in the NAc. A more detailed mitochondrial gene expression analysis revealed that in particular mitochondrial DNA-encoded subunits of the oxidative phosphorylation complexes were altered in the PFC. The comparison of our data with a reanalyzed transcriptome data set of chronic variable stress mice and major depression disorder subjects showed that the changes in mitochondrial DNA-encoded genes are a feature generalizing to other chronic stress-protocols as well and might have translational relevance. Finally, we provide evidence for changes in mitochondrial outputs in the PFC following chronic stress that are indicative of mitochondrial dysfunction. Collectively, our work reinforces the idea that changes in mitochondrial gene expression are key players in the prefrontal adaptations observed in individuals with high behavioral susceptibility and resilience to chronic stress.

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Transcriptional profiling of mitochondria associated genes in prefrontal cortex of subjects with major depressive disorder

Cited by 36 publications

References 48 publications

Mitochondria and Mood: Mitochondrial Dysfunction as a Key Player in the Manifestation of Depression

Mitochondria and Mood: Mitochondrial Dysfunction as a Key Player in the Manifestation of Depression

Die Kraftwerke der Zellen- über die Behandlung von psychiatrischen Symptomen bei Patienten mit Mitochondriopathien

Mitochondrial gene signature in the prefrontal cortex for differential susceptibility to chronic stress

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