Transcriptional network regulation of the brassinosteroid signaling pathway by the BES1–TPL–HDA19 co-repressor complex

Kim, Hye Min; Shim, Donghwan; Moon, Suyun; Lee, Jinsu; Bae, Wonsil; Choi, Hyunmo; Kim, Kyung-Hwan; Ryu, Hojin

doi:10.1007/s00425-019-03233-z

Cited by 27 publications

(20 citation statements)

References 33 publications

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“…This complex allows the suppression of ABA signaling during seedling development. Formation of a protein complex between BES1 or BZR1 and HDA19 is essential for regulation of drought stress tolerance [ 48 ].…”

Section: The Priming Phenomenonmentioning

confidence: 99%

Linking Brassinosteroid and ABA Signaling in the Context of Stress Acclimation

Bulgakov

Авраменко

2020

IJMS

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The important regulatory role of brassinosteroids (BRs) in the mechanisms of tolerance to multiple stresses is well known. Growing data indicate that the phenomenon of BR-mediated drought stress tolerance can be explained by the generation of stress memory (the process known as ‘priming’ or ‘acclimation’). In this review, we summarize the data on BR and abscisic acid (ABA) signaling to show the interconnection between the pathways in the stress memory acquisition. Starting from brassinosteroid receptors brassinosteroid insensitive 1 (BRI1) and receptor-like protein kinase BRI1-like 3 (BRL3) and propagating through BR-signaling kinases 1 and 3 (BSK1/3) → BRI1 suppressor 1 (BSU1) ―‖ brassinosteroid insensitive 2 (BIN2) pathway, BR and ABA signaling are linked through BIN2 kinase. Bioinformatics data suggest possible modules by which BRs can affect the memory to drought or cold stresses. These are the BIN2 → SNF1-related protein kinases (SnRK2s) → abscisic acid responsive elements-binding factor 2 (ABF2) module; BRI1-EMS-supressor 1 (BES1) or brassinazole-resistant 1 protein (BZR1)–TOPLESS (TPL)–histone deacetylase 19 (HDA19) repressor complexes, and the BZR1/BES1 → flowering locus C (FLC)/flowering time control protein FCA (FCA) pathway. Acclimation processes can be also regulated by BR signaling associated with stress reactions caused by an accumulation of misfolded proteins in the endoplasmic reticulum.

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Section: The Priming Phenomenonmentioning

confidence: 99%

Linking Brassinosteroid and ABA Signaling in the Context of Stress Acclimation

Bulgakov

Авраменко

2020

IJMS

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“…The past decade has seen unprecedented progress in understanding the signaling pathways controlling the plant responses to stresses, which has been summarized in prior reviews [16][17][18]. Activation of these signaling pathways usually results in the dramatic transcriptional reprogramming to initiate a set of stress responses [19][20][21]. There is increasing evidence indicating that this transcriptional reprogramming and regulation of stress-responsive genes involves diverse epigenetic processes and elements, such as DNA methylation, histone modification, chromatin remodeling and non-coding RNAs [22][23][24].…”

Section: Introductionmentioning

confidence: 99%

Insight into the Role of Epigenetic Processes in Abiotic and Biotic Stress Response in Wheat and Barley

Kong

Liu

Wang

et al. 2020

IJMS

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Environmental stresses such as salinity, drought, heat, freezing, heavy metal and even pathogen infections seriously threaten the growth and yield of important cereal crops including wheat and barley. There is growing evidence indicating that plants employ sophisticated epigenetic mechanisms to fine-tune their responses to environmental stresses. Here, we provide an overview of recent developments in understanding the epigenetic processes and elements—such as DNA methylation, histone modification, chromatin remodeling, and non-coding RNAs—involved in plant responses to abiotic and biotic stresses in wheat and barley. Potentials of exploiting epigenetic variation for the improvement of wheat and barley are discussed.

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“…We thus postulated that BES1 recruits additional trans-factors to repress gene expression. Previous studies showed that BES1 usually accompanies TPL and TPL-RELATED (TPR) proteins in processes requiring predominantly repressive activities ( Ryu et al., 2014 ; Espinosa-Ruiz et al., 2017 ; Kim et al., 2019 ). Yeast-two-hybrid (Y2H) assays performed in this study supported the BES1-TPL interaction ( Figure S8 ).…”

Section: Resultsmentioning

confidence: 99%

Brassinosteroids Regulate Circadian Oscillation via the BES1/TPL-CCA1/LHY Module in Arabidopsis thaliana

et al. 2020

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Summary Brassinosteroids (BRs) regulate a variety of physiological processes in plants via extensive crosstalk with diverse biological signaling networks. Although BRs are known to reciprocally regulate circadian oscillation, the molecular mechanism underlying BR-mediated regulation of circadian clock remains unknown. Here, we demonstrate that the BR-activated transcription factor bri1 -EMS-SUPPRESSOR 1 (BES1) integrates BR signaling into the circadian network in Arabidopsis. BES1 repressed expression of CIRCADIAN CLOCK-ASSOCIATED 1 ( CCA1 ) and LATE ELONGATED HYPOCOTYL ( LHY ) at night by binding to their promoters, together with TOPLESS (TPL). The repression of CCA1 and LHY by BR treatment, which occurred during the night, was compromised in bes1-ko and tpl-8 mutants. Consistently, long-term treatment with BR shortened the circadian period, and BR-induced rhythmic shortening was impaired in bes1-ko and tpl-8 single mutants and in the cca1-1lhy-21 double mutant. Overall, BR signaling is conveyed to the circadian oscillator via the BES1/TPL-CCA1/LHY module, contributing to gating diurnal BR responses in plants.

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Transcriptional network regulation of the brassinosteroid signaling pathway by the BES1–TPL–HDA19 co-repressor complex

Cited by 27 publications

References 33 publications

Linking Brassinosteroid and ABA Signaling in the Context of Stress Acclimation

Linking Brassinosteroid and ABA Signaling in the Context of Stress Acclimation

Insight into the Role of Epigenetic Processes in Abiotic and Biotic Stress Response in Wheat and Barley

Brassinosteroids Regulate Circadian Oscillation via the BES1/TPL-CCA1/LHY Module in Arabidopsis thaliana

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