1995
DOI: 10.1097/00007890-199506150-00018
|View full text |Cite
|
Sign up to set email alerts
|

TRANSCRIPTIONAL INHIBITION OF INSULIN BY FK506 AND POSSIBLE INVOLVEMENT OF FK506 BINDING PROTEIN-12 IN PANCREATIC Β-Cell

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1

Citation Types

1
19
0

Year Published

2000
2000
2014
2014

Publication Types

Select...
8

Relationship

0
8

Authors

Journals

citations
Cited by 19 publications
(20 citation statements)
references
References 0 publications
1
19
0
Order By: Relevance
“…9 The diabetogenic action of FK506 on pancreatic b cells is due to transcriptional inhibition of insulin. 10 No diabetogenic adverse effects were observed in the 12 patients treated with FK506 in this long term study, but it has been reported that diabetes mellitus exacerbated by FK506 can be relieved by dose reduction. 9 In summary, long term use of FK506 in low doses (2-4.5 mg/day) is safe and effective in patients with generalised MG in association with prednisolone reduction.…”
Section: Discussionmentioning
confidence: 61%
“…9 The diabetogenic action of FK506 on pancreatic b cells is due to transcriptional inhibition of insulin. 10 No diabetogenic adverse effects were observed in the 12 patients treated with FK506 in this long term study, but it has been reported that diabetes mellitus exacerbated by FK506 can be relieved by dose reduction. 9 In summary, long term use of FK506 in low doses (2-4.5 mg/day) is safe and effective in patients with generalised MG in association with prednisolone reduction.…”
Section: Discussionmentioning
confidence: 61%
“…Several studies have demonstrated that tacroli-mus inhibits insulin secretion from the beta-cell [19,20,21,22,23]. Following a 2-week treatment course, tacrolimus reversibly suppressed insulin gene transcription in normal rats [23]. Furthermore, there are several reports suggesting that tacrolimus damages the beta-cell directly.…”
Section: Discussionmentioning
confidence: 99%
“…This calcium/calmodulin-dependent serine/threonine protein phosphatase is unique among the protein phosphatases and has been conserved from yeast to man. Calcineurin is widely distributed among tissues, including islet cells of the endocrine pancreas (1921), skeletal muscle, heart, neurons, and adipocytes (22, 23). Calcineurin is a key enzyme in many cellular processes including antigen-stimulated T-lymphocyte activation, skeletal-muscle gene expression and remodeling, and the formation of the embryonic cardiovascular system (24).…”
Section: Structure and Function Of Calcineurinmentioning
confidence: 99%