Transcriptional evidence for transient regulation of muscle regeneration by brown adipose transplant in the rotator cuff
Chang Gui,
Gretchen Meyer
Abstract:Chronic rotator cuff (RC) injuries can lead to a degenerative microenvironment that favors chronic inflammation, fibrosis, and fatty infiltration. Recovery of muscle structure and function will ultimately require a complex network of muscle resident cells, including satellite cells, fibro‐adipogenic progenitors (FAPs), and immune cells. Recent work suggests that signaling from adipose tissue and progenitors could modulate regeneration and recovery of function, particularly promyogenic signaling from brown or b… Show more
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