Transcriptional effects of polyethylene microplastics ingestion in developing zebrafish (Danio rerio)

LeMoine, Christophe M. R.; Kelleher, Bailey M.; Lagarde, R; Northam, Caleb; Elebute, Oluwadara; Cassone, Bryan J.

doi:10.1016/j.envpol.2018.08.084

Cited by 144 publications

(67 citation statements)

References 88 publications

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“…In many cases, MPs/NPs were found accumulated in larvae or adult gut [77,[79][80][81][82][83], and in some cases in gill and liver [79]. Histopathology is most prominently observed for these tissues as well [74,75,77,79,[83][84][85].…”

Section: Toxicity Of Mps/nps In Fishesmentioning

confidence: 99%

Toxicity of Microplastics and Nanoplastics in Mammalian Systems

Yong

Valiyaveettil

Tang

2020

IJERPH

521

280

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Fragmented or otherwise miniaturized plastic materials in the form of micro- or nanoplastics have been of nagging environmental concern. Perturbation of organismal physiology and behavior by micro- and nanoplastics have been widely documented for marine invertebrates. Some of these effects are also manifested by larger marine vertebrates such as fishes. More recently, possible effects of micro- and nanoplastics on mammalian gut microbiota as well as host cellular and metabolic toxicity have been reported in mouse models. Human exposure to micro- and nanoplastics occurs largely through ingestion, as these are found in food or derived from food packaging, but also in a less well-defined manner though inhalation. The pathophysiological consequences of acute and chronic micro- and nanoplastics exposure in the mammalian system, particularly humans, are yet unclear. In this review, we focus on the recent findings related to the potential toxicity and detrimental effects of micro- and nanoplastics as demonstrated in mouse models as well as human cell lines. The prevailing data suggest that micro- and nanoplastics accumulation in mammalian and human tissues would likely have negative, yet unclear long-term consequences. There is a need for cellular and systemic toxicity due to micro- and nanoplastics to be better illuminated, and the underlying mechanisms defined by further work.

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Section: Toxicity Of Mps/nps In Fishesmentioning

confidence: 99%

Toxicity of Microplastics and Nanoplastics in Mammalian Systems

Yong

Valiyaveettil

Tang

2020

IJERPH

521

280

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“…All fish (MP and control) were kept under these conditions for either 4 or 10 days, corresponding to 9 dpf and 15 dpf, respectively. Under similar experimental conditions, this treatment previously yielded consistent ingestion and accumulation of MP in all zebrafish larvae [ 13 ]. All treatments were maintained in a 27 °C water bath for the duration of the experiment.…”

Section: Methodsmentioning

confidence: 59%

“…As MP can easily be ingested, their presence in aquatic environments poses a potential risk to many animal species, chronically exposing them to this pervasive pollutant. In aquatic animals, MP primarily accumulate both in the alimentary canal and respiratory structures in adult animals, though they appear to be limited to the intestine in aquatic larvae [ 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of MP Polyethylene Microparticles on Microbiome and Inflammatory Response of Larval Zebrafish

Kurchaba

Cassone

Northam

et al. 2020

Toxics

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Plastic polymers have quickly become one of the most abundant materials on Earth due to their low production cost and high versatility. Unfortunately, some of the discarded plastic can make its way into the environment and become fragmented into smaller microscopic particles, termed secondary microplastics (MP). In addition, primary MP, purposely manufactured microscopic plastic particles, can also make their way into our environment via various routes. Owing to their size and resilience, these MP can then be easily ingested by living organisms. The effect of MP particles on living organisms is suspected to have negative implications, especially during early development. In this study, we examined the effects of polyethylene MP ingestion for four and ten days of exposure starting at 5 days post-fertilization (dpf). In particular, we examined the effects of polyethylene MP exposure on resting metabolic rate, on gene expression of several inflammatory and oxidative stress linked genes, and on microbiome composition between treatments. Overall, we found no evidence of broad metabolic disturbances or inflammatory markers in MP-exposed fish for either period of time. However, there was a significant increase in the oxidative stress mediator L-FABP that occurred at 15 dpf. Furthermore, the microbiome was disrupted by MP exposure, with evidence of an increased abundance of Bacteroidetes in MP fish, a combination frequently found in intestinal pathologies. Thus, it appears that acute polyethylene MP exposure can increase oxidative stress and dysbiosis, which may render the animal more susceptible to diseases.

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“…Qiang and Cheng (2019), also reported that MPs induced upregulated expression of inflammation and oxidative stress related genes along with reductions in the swimming speed and distance of zebrafish larvae exposed at early stages. The presence of fluorescent polystyrene NPs during development decreased the heart rate and changed the behavior of the zebrafish larvae exposed at early stages (Pitt et al, 2018a), but, on the other hand Lemoine et al (2018) did not find effects in terms of growth, development or metabolism despite the changes induced in gene expression.…”

Section: Nps-mps Effects In Zebrafishmentioning

confidence: 79%

“…NPs and MPs can accumulate in the fish tissues, as proved by Catarino et al (2019) that exposed embryos to commercial fluorescent-labelled polystyrene NPs and generate the accumulation of the fluorophore in the internal tissues. Particularly the accumulation of MPs was located in the gastrointestinal tract dependently of concentration (Lemoine et al, 2018). Zebrafish also presented cracking of villi and splitting of enterocytes by MPs of 70 µm size (Lei et al, 2018).…”

Section: Nps-mps Effects In Zebrafishmentioning

confidence: 97%

Nanoplastics in the Environment and the Effects on the Zebrafish

León¹,

Cotto²,

Márquez³

2019

American Journal of Engineering and Applied Sciences

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Plastic is one of the most used materials in the world, adopted in almost all activities of human life, but due to the high persistence and durability in the environment, it is causing pollution problems. Through different processes, small particles of polymers are emerging and the effects on the health are still unknown. The Danio rerio (zebrafish) is a model organism that serves as a reference for the assessment of the safety of Nanoplastics (NPs) and Microplastics (MPs). The effects on development, central nervous system, behavior and genetic regulation, are some of the evidences that are already available thanks to the studies developed in recent years. The potential exacerbation of toxicity by co-exposure of the NPs and MP with other contaminants has been demonstrated through several studies. Furthermore, the challenge that must be overcome is the lack of uniformity in the analytical methodology that helps to generate conclusive and parallel results.

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Transcriptional effects of polyethylene microplastics ingestion in developing zebrafish (Danio rerio)

Cited by 144 publications

References 88 publications

Toxicity of Microplastics and Nanoplastics in Mammalian Systems

Toxicity of Microplastics and Nanoplastics in Mammalian Systems

Effects of MP Polyethylene Microparticles on Microbiome and Inflammatory Response of Larval Zebrafish

Nanoplastics in the Environment and the Effects on the Zebrafish

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