Transcriptional control of central T cell tolerance by NR4A family nuclear receptors
Hailyn V. Nielsen,
James L. Mueller,
Ryosuke Hiwa
et al.
Abstract:Although deletion of self-reactive thymocytes and their diversion into regulatory T cell (Treg) lineage are critical for immune tolerance and homeostasis, the molecular pathways that link antigen recognition to these fates are incompletely understood. The Nr4a nuclear hormone receptors are transcriptionally upregulated in response to TCR signaling in the thymus and are implicated in both deletion and diversion, but the mechanisms by which they operate are not clear. Redundancy among the family members and thei… Show more
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