Transcriptional Control of Cell Fate Determination in Antigen-Experienced CD8 T Cells

Tsuda, Shanel; Pipkin, Matthew E.

doi:10.1101/cshperspect.a037945

Cited by 4 publications

(2 citation statements)

References 130 publications

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“…Activation of a specialized antigen-presenting cells (APC) is the first step in the initiation of adaptive immunity ( Figure 3 ). Antigen is denoting an extraneous molecule that initiates immune response by reacting with immune cells [ 44 , 45 ]. Antigen must be a foreign alien (“non-self”) molecule.…”

Section: Essentialsmentioning

confidence: 99%

Nanotechnology-Based RNA Vaccines: Fundamentals, Advantages and Challenges

Pozharov

Minko

2023

Pharmaceutics

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Over the past decades, many drugs based on the use of nanotechnology and nucleic acids have been developed. However, until recently, most of them remained at the stage of pre-clinical development and testing and did not find their way to the clinic. In our opinion, the main reason for this situation lies in the enormous complexity of the development and industrial production of such formulations leading to their high cost. The development of nanotechnology-based drugs requires the participation of scientists from many and completely different specialties including Pharmaceutical Sciences, Medicine, Engineering, Drug Delivery, Chemistry, Molecular Biology, Physiology and so on. Nevertheless, emergence of coronavirus and new vaccines based on nanotechnology has shown the high efficiency of this approach. Effective development of vaccines based on the use of nucleic acids and nanomedicine requires an understanding of a wide range of principles including mechanisms of immune responses, nucleic acid functions, nanotechnology and vaccinations. In this regard, the purpose of the current review is to recall the basic principles of the work of the immune system, vaccination, nanotechnology and drug delivery in terms of the development and production of vaccines based on both nanotechnology and the use of nucleic acids.

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Section: Essentialsmentioning

confidence: 99%

Nanotechnology-Based RNA Vaccines: Fundamentals, Advantages and Challenges

Pozharov

Minko

2023

Pharmaceutics

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“…Naïve Cd8 T cells become activated in response to infections or cancer and develop into diverse effector (T EFF ), memory (T MEM ) or exhausted (T EX ) cell phylogenies( 1, 2 ). Successful adaptive immunity forms following acutely resolved infections and is maintained long-term by memory T stem cells (T SCM ) that self-renew under homeostatic conditions, and that regenerate both T EFF and T MEM cell populations following antigen re-exposure (3, 4 ).…”

Section: Introductionmentioning

confidence: 99%

Mll1 pioneers histone H3K4me3 deposition and promotes formation of CD8⁺T stem cell memory

Getzler

Frederick

Diao

et al. 2023

Preprint

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Memory Cd8+ T cells with stem cell-like properties (TSCM) sustain long-lived adaptive immunity to intracellular pathogens and tumors. However, the chromatin regulatory factors (CRFs) and transcriptional dynamics that program their differentiation are unclear. Using an RNA interference screen of all CRFs we discovered that Mll1 was essential during initial T cell receptor (TCR) stimulation of naive Cd8+ T cells to establish long-lived memory and progenitor TSCM-like cells during acute and during chronic viral infections and tumors. We demonstrate that primary TCR stimulation drives de novo histone H3 lysine 4 trimethylation (H3K4me3) deposition and RNA polymerase II pausing at genes whose RNA velocities explain single-cell trajectories that diversify nascent effector and memory cell states early during viral infection. Mll1 was essential for induced H3K4me3 at half of all TCR-activated transcription start sites (> 7,000 regions), especially those specific to memory cells. Our results suggest that Mll1-dependent H3K4me3 and regulation of RNA Pol II pausing govern dynamic transcriptional states that patterns TMEM cell diversity.

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T cell fate decisions during memory cell generation with aging

Sturmlechner

Jain

et al. 2023

Seminars in Immunology

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Transcriptional Control of Cell Fate Determination in Antigen-Experienced CD8 T Cells

Cited by 4 publications

References 130 publications

Nanotechnology-Based RNA Vaccines: Fundamentals, Advantages and Challenges

Nanotechnology-Based RNA Vaccines: Fundamentals, Advantages and Challenges

Mll1 pioneers histone H3K4me3 deposition and promotes formation of CD8⁺T stem cell memory

T cell fate decisions during memory cell generation with aging

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Transcriptional Control of Cell Fate Determination in Antigen-Experienced CD8 T Cells

Cited by 4 publications

References 130 publications

Nanotechnology-Based RNA Vaccines: Fundamentals, Advantages and Challenges

Nanotechnology-Based RNA Vaccines: Fundamentals, Advantages and Challenges

Mll1 pioneers histone H3K4me3 deposition and promotes formation of CD8+T stem cell memory

T cell fate decisions during memory cell generation with aging

Contact Info

Product

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Mll1 pioneers histone H3K4me3 deposition and promotes formation of CD8⁺T stem cell memory