Transcriptional co-factors and hepatic energy metabolism

Sommerfeld, Anke; Krones-Herzig, Anja; Herzig, Stephan

doi:10.1016/j.mce.2010.11.020

Cited by 14 publications

(10 citation statements)

References 167 publications

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“…Hepatic metabolic adaptations leading to triglyceride accumulation (hepatosteatosis) and increased gluconeogenesis are primarily mediated by gene expression adjustments [15]. These alterations are frequently associated with aging and obesity and favor the development of systemic insulin resistance, the alteration of metabolic flexibility upon nutritional status changes [6].…”

Section: Discussionmentioning

confidence: 99%

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Analysis of Sterol-Regulatory Element-Binding Protein 1c Target Genes in Mouse Liver during Aging and High-Fat Diet

Capel

Rolland-Valognes²,

Dacquet³

et al. 2013

Lifestyle Genomics

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Background: The sterol regulatory element-binding protein (SREBP) 1c contributes to the transcriptional coordination of cholesterol, fatty acid, and carbohydrate metabolisms. Alterations in these processes accelerate the progression of hepatic steatosis and insulin resistance during aging and obesity. Methods: Using an ex vivo chromatin immunoprecipitation coupled to microarray (ChIP-on-chip) technique combined with genome-wide gene expression analysis, we analyzed the transcriptomic adaptations mediated by Srebp-1c binding to gene promoters in the liver of mice fed with a low-fat diet or a high-fat diet (HFD) for either 1 or 12 months. Results: Aging had a higher transcriptional impact than HFD and modified the expression of genes involved in fatty acid oxidation and oxidative stress. HFD was associated with a marked induction of genes involved in lipid and cholesterol metabolism. The prolonged high-fat feeding together with the aging effects stimulates inflammatory pathways. ChIP-on-chip applied to aging and HFD analyses revealed that the binding of SREBP-1c to a series of promoters accompanied a paralleled modification of gene expression. Therefore, SREBP-1c could play a role in aging and high-fat feeding through the regulation of genes involved in lipid metabolism and inflammatory response. Conclusions: This study represents an original ex vivo experiment to elucidate the molecular events involved in metabolic disorders.

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Section: Discussionmentioning

confidence: 99%

“…The development of hepatic insulin resistance is complex and involves several cofactors and regulatory pathways [15]. However, the contribution of SREBP-1c-dependent adaptations in hepatic metabolism was identified [16].…”

Section: Introductionmentioning

confidence: 99%

Analysis of Sterol-Regulatory Element-Binding Protein 1c Target Genes in Mouse Liver during Aging and High-Fat Diet

Capel

Rolland-Valognes²,

Dacquet³

et al. 2013

Lifestyle Genomics

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show abstract

“…CRF, corticotrophin-releasing factor; ACTH, adrenocorticotrophin hormone; GLUT4, glucose transporter 4; IGF-1, insulin-like growth factor-1; AMPK, AMP kinase; LXR, liver X receptor; RXR, retinol X receptor; PEPCK, PEP carboxykinase; PKLR, pyruvate kinase; G6Pase, glucose-6-phosphatase; PGC1α, PPAR-γ co-activator-1; SRC-1, steroid receptor co-activator 1; CBP, CREB-binding protein; CREB, cAMP-response element binding protein; C/EBP, CCAAT/enhancer binding protein; GR, glucocorticoid receptor; GRE; glucocorticoid response element; HNF, hepatic nuclear factor; COUP, chicken ovalbumin upstream promotertranscription factor; FoxO1, foxhead box protein O1. determined by the physical recruitment and/or exchange of transcriptional co-activators/repressors to the GR, which have emerged as a critical regulatory layer in the control of tissue-specific and systemic energy homeostasis [52]. Indeed, during fasting, hepatic nuclear receptor co-factor peroxisome proliferator-activated receptor coactivator 1α (PGC-1α) [53] is activated in response to catecholamine/glucagon-triggered cAMP/cAMP responsive element binding protein (CREB) signaling [54].…”

Section: Gcs In Glucose Homeostasismentioning

confidence: 99%

Glucocorticoid hormones and energy homeostasis

Guia

Rose

Herzig³

2014

Hormone Molecular Biology and Clinical Investigation

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Glucocorticoids (GC) and their cognate intracellular receptor, the glucocorticoid receptor (GR), have been characterised as critical checkpoints in the endocrine control of energy homeostasis in mammals. Indeed, aberrant GC action has been linked to a variety of severe metabolic diseases, including obesity, insulin resistance and type 2 diabetes. As a steroid-binding member of the nuclear receptor superfamily of transcription factors, the GR translocates into the cell nucleus upon GC binding where it serves as a transcriptional regulator of distinct GC-responsive target genes that are - in many cases - associated with glucose and lipid regulatory pathways and thereby intricately control both physiological and pathophysiological systemic energy homeostasis. Here, we summarize the current knowledge of GC/GR function in energy metabolism and systemic metabolic dysfunction, particularly focusing on glucose and lipid metabolism.

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“…Therefore it is very likely that disturbances in hepatic metabolism are linked to events contributing to the metabolic syndrome [91,92]. Several processes leading to a fatty liver phenotype are discussed.…”

Section: Lipid Metabolism and Nafldmentioning

confidence: 99%

Beyond the Role of Dietary Protein and Amino Acids in the Prevention of Diet-Induced Obesity

Petzke

Freudenberg

Klaus

2014

IJMS

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High-protein diets have been shown to prevent the development of diet-induced obesity and can improve associated metabolic disorders in mice. Dietary leucine supplementation can partially mimic this effect. However, the molecular mechanisms triggering these preventive effects remain to be satisfactorily explained. Here we review studies showing a connection between high protein or total amino nitrogen intake and obligatory water intake. High amino nitrogen intake may possibly lower lipid storage, and prevent insulin resistance. Suggestions are made for further systematical studies to explore the relationship between water consumption, satiety, and energy expenditure. Moreover, these examinations should better distinguish between leucine-specific and unspecific effects. Research in this field can provide important information to justify dietary recommendations and strategies in promoting long-term weight loss and may help to reduce health problems associated with the comorbidities of obesity.

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Transcriptional co-factors and hepatic energy metabolism

Cited by 14 publications

References 167 publications

Analysis of Sterol-Regulatory Element-Binding Protein 1c Target Genes in Mouse Liver during Aging and High-Fat Diet

Analysis of Sterol-Regulatory Element-Binding Protein 1c Target Genes in Mouse Liver during Aging and High-Fat Diet

Glucocorticoid hormones and energy homeostasis

Beyond the Role of Dietary Protein and Amino Acids in the Prevention of Diet-Induced Obesity

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