Transcriptional, biochemical and histological alterations in adult zebrafish (Danio rerio) exposed to benzotriazole ultraviolet stabilizer-328

Hemalatha, Devan; Rangasamy, Basuvannan; Nataraj, Bojan; Maharajan, Kannan; Narayanasamy, Arul; Ramesh, Mathan

doi:10.1016/j.scitotenv.2020.139851

Cited by 39 publications

(14 citation statements)

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“…An activation of aryl hydrocarbon receptor pathway in zebra sh eleuthero-embryos was observed after their being exposed to BUVSs. Besides, these compounds are also reported to cause oxidative stress damages in Daphnia magna and zebra sh (Giraudo et al, 2017;Hemalatha et al, 2020). More recently, Li et al (2019) and Li et al (2020) revealed their in ammatory effects in sh, which was potentially caused through the AHR-IL17/IL22 pathways.…”

Section: Introductionmentioning

confidence: 99%

“…Consequently, BUVSs have been detected in environmental matrices such as surface water (Parajulee et al, 2018), wastewater (Carpinteiro et al, 2010), sewage sludge (Lu et al, 2017), sediment (Nakata et al, 2009), soil (Lai et al, 2014), and indoor dust (Kim et al, 2012). Relatively few studies reported BUVSs in aquatic biota, mainly in marine invertebrates, shes, coastal birds, and marine mammals (Hemalatha et al, 2020;Kim et al, 2012;Nakata et al, 2009), demonstrating their bioaccumulation potential. What's more, it's been reported that BUVSs are found in human urine and breast milk in recent years (Kim et al, 2019;Wang et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…BUVSs have been considered to be persistent in environment (Nakata et al, 2010) and their lipophilicity/hydrophilicity (log Kow:4.31-8.28) property is the main factor governing their accumulation potential in aquatic organisms (Hemalatha et al, 2020;Xing et al, 2018). For instance, UV-327 showed a signi cant bioaccumulation property in marine mammals from the western North Paci c Ocean with a bioconcentration factor (BCF) value as high as that of persistent organochlorine pesticide, hexachlorocyclohexane (37 000) (Hemalatha et al, 2020). In addition, high bioaccumulation factor (BAF) of BUVSs were also observed in fresh water aquatic organisms from the Pearl River basin in China, and some of the BUVSs congeners showed trophic magni cation behavior with trophic magni cation factor (TMF) > 1 (Xiong, 2017).…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Effect of copper on bioconcentration of benzotriazole ultraviolet stabilizers (BUVSs) in common carp (Cyprinus carpio)

Zhao

Bekele

Zhao

2022

Environmental Research

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Effect of copper on bioconcentration of benzotriazole ultraviolet stabilizers (BUVSs) in common carp (Cyprinus carpio)

Zhao

Bekele

Zhao

2022

Environmental Research

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“…In contrast, specific target organ toxicity to liver and kidneys was stated for repeated oral administration to rats and beagle dogs (ECHA 2013;Geigy 1970;Til et al 1968). Chronic exposure of fish induced oxidative stress in the liver so that significant effects to antioxidant enzymes as well as tissue damage were reported (Hemalatha et al 2020). Furthermore, accumulation of UV 328 in fish liver was found after chronic food-borne exposure together with transcriptional changes in gene expression (Giraudo et al 2020).…”

mentioning

confidence: 99%

Human metabolism and kinetics of the UV absorber 2-(2H-benzotriazol-2-yl)-4,6-di-tert-pentylphenol (UV 328) after oral administration

et al. 2021

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Abstract2-(2H-Benzotriazol-2-yl)-4,6-di-tert-pentylphenol (UV 328; CAS: 25973-55-1) is an ultraviolet light (UV) absorber which belongs to the class of hydroxy phenol benzotriazoles. Therefore, UV 328 is added to plastics and other polymers due to its photostability to prevent discoloration and prolong product stability which may result in an exposure of consumers. However, information about the toxic effects on humans and the human metabolism are still lacking. In the present study, human metabolism pathways of UV 328 and its elimination kinetics were explored. For that purpose, three healthy volunteers were orally exposed to a single dose of 0.3 mg UV 328/kg bodyweight. UV 328 and its metabolites were investigated in blood and urine samples collected until 48 and 72 h after exposure, respectively. Thereby, previously published analytical procedures were applied for the sample analysis using dispersive liquid–liquid microextraction and subsequent measurement via gas chromatography coupled to tandem mass spectrometry with advanced electron ionization. UV 328 was found to be oxidized at its alkyl side chains leading to the formation of hydroxy and/or oxo function with maximum blood concentrations at 8–10 h after exposure for UV 328-6/3-OH, UV 328-4/3-OH and UV 328-4/3-CO. In contrast, a plateau for UV 328-4/3-CO-6/3-OH levels was reached around 10 h post-dosage. The highest blood levels were found for native UV 328 at 8 h after ingestion. Furthermore, biphasic elimination kinetics in blood were revealed for almost all detected metabolites. UV 328 and its metabolites did not occur in blood as conjugates. The renal elimination kinetics were very similar with the kinetics in blood. However, the prominence of the metabolites in urine was somewhat different compared to blood. In contrast, mostly conjugated metabolites occurred for renal elimination. In urine, UV 328-4/3-CO-6/3-OH was found to be the most dominant urinary biomarker followed by UV 328-6/3-OH and UV 328-4/3-OH. In total, approximately 0.1% of the orally administered dose was recovered in urine within 72 h. Although high levels of UV 328 in blood proved good resorption and high systemic availability of the substance in the human body, the urine results revealed a rather low quantitative metabolism and urinary excretion rate. Consequently, biliary excretion as part of the enterohepatic cycle and elimination via feces are assumed to be the preferred pathways instead of renal elimination.

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Embryonic Exposure to Benzotriazole Ultraviolet Stabilizer 327 Alters Behavior of Rainbow Trout Alevin

Eriksson,

Dubiel,

Zink

et al. 2024

Enviro Toxic and Chemistry

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Benzotriazole ultraviolet stabilizers (BUVSs) are used in great quantities during industrial production of a variety of consumer and industrial goods. Due to leaching and spill, BUVSs are detectable ubiquitously in the environment. As of May 2023, citing concerns related to bioaccumulation, biomagnification, and environmental persistence, (B)UV(S)‐328 was recommended to be listed under Annex A of the Stockholm Convention on Persistent Organic Pollutants. However, a phase out of UV‐328 could result in a regrettable substitution, as the replacement chemical(s) could cause similar or unpredicted toxicity in vivo, relative to the UV‐328. Therefore, the influence of UV‐327, a potential replacement of UV‐328, was investigated with respected to early life development of newly fertilized rainbow trout embryos (Oncorhynchus mykiss), microinjected with environmentally relevant concentrations of UV‐327. Developmental parameters (standard length), energy consumption (yolk area), heart function, blue sac disease, mortality, and behaviour were investigated. Alevins at 14 days post‐hatching, exposed to 107 ng UV‐327 g‐1 egg, presented significant signs of hyperactivity, as they moved on average 1.8‐fold the distance and at 1.5‐fold the velocity of controls. Although a substantial reduction in body burden of UV‐327 was observed at hatching, it is postulated that UV‐327, due to its lipophilic properties, interfered with neurological development and signaling from the onset of neurogenesis. If these results hold true across multiple taxa and species, a potential contributor to neurodevelopmental disorders might have been identified. These findings suggest that UV‐327 pose an unknown hazard to rainbow trout embryos and alevins, rendering UV‐327 a potential regrettable substitution to UV‐328. However, a qualified statement on a regrettable substitution requires a comparative investigation on the teratogenic effects between the two BUVSs.

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Transcriptional, biochemical and histological alterations in adult zebrafish (Danio rerio) exposed to benzotriazole ultraviolet stabilizer-328

Cited by 39 publications

References 85 publications

Effect of copper on bioconcentration of benzotriazole ultraviolet stabilizers (BUVSs) in common carp (Cyprinus carpio)

Effect of copper on bioconcentration of benzotriazole ultraviolet stabilizers (BUVSs) in common carp (Cyprinus carpio)

Human metabolism and kinetics of the UV absorber 2-(2H-benzotriazol-2-yl)-4,6-di-tert-pentylphenol (UV 328) after oral administration

Embryonic Exposure to Benzotriazole Ultraviolet Stabilizer 327 Alters Behavior of Rainbow Trout Alevin

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