Transcriptional autoregulation in development

Crews, Stephen T.; Pearson, Joseph C.

doi:10.1016/j.cub.2009.01.015

Cited by 99 publications

(102 citation statements)

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“…Autoregulation, a transcriptional strategy in which a given transcription factor binds to its own promoter to either activate or repress its own transcription, is employed by a wide variety of eukaryotes to refine and maintain transcription levels after induction of gene expression by transient extracellular signals (Bateman, 1998;Crews and Pearson, 2009). The occurrence of an autoregulatory loop may be positively correlated with the developmental or physiological importance of a transcription factor, and master developmental regulators that control large (2942) tggGGCCCCCCctt (2960) Gao et al (2008); this study Gesneriaceae (Asterids) CYC1D a The top half is actinomorphic species, and the bottom half is zygomorphic species.…”

Section: A Double Positive Autoregulatory Feedback Loop Accounting Fomentioning

confidence: 99%

“…number of genes are usually autoregulated as their expression levels must be tightly controlled (Crews and Pearson, 2009). A positive autoregulatory loop is a general mechanism to amplify and maintain gene expression that arises from transient inputs to create morphological and physiological effects during development (Crews and Pearson, 2009).…”

Section: A Double Positive Autoregulatory Feedback Loop Accounting Fomentioning

confidence: 99%

“…A positive autoregulatory loop is a general mechanism to amplify and maintain gene expression that arises from transient inputs to create morphological and physiological effects during development (Crews and Pearson, 2009). The autoregulation of P. heterotricha CYC1 should be a positive loop, a common feature of developmental transcription factors in animals and plants (Crews and Pearson, 2009).…”

Section: A Double Positive Autoregulatory Feedback Loop Accounting Fomentioning

confidence: 99%

“…Classical examples include Myocyte enhancing factor2 and Twist, which function in Drosophila melanogaster embryonic muscle development (Crews and Pearson, 2009), and DEFICIENS and GLOBOSA, which specify petal and stamen identities in snapdragon (Schwarz-Sommer et al, 1992). In our study, P. heterotricha CYC1C protein binds to both its own promoter and the CYC1D promoter, and vice versa, indicating that a double positive autoregulatory feedback loop has also been employed by P. heterotricha CYC1 genes to maintain their asymmetric expression in P. heterotricha flowers (Figure 8).…”

Section: A Double Positive Autoregulatory Feedback Loop Accounting Fomentioning

confidence: 99%

“…Increasing evidence indicates that CYC2 clade genes, specific for the core eudicots, were repeatedly recruited to function in the control of floral zygomorphy based on their strong, dorsoventrally asymmetric expression (Luo et al, 1996(Luo et al, , 1999Feng et al, 2006;Zachgo, 2007, 2009;Broholm et al, 2008;Gao et al, 2008;Kim et al, 2008;Wang et al, 2008Wang et al, , 2010Preston and Hileman, 2009;Song et al, 2009;Zhang et al, 2010;Howarth et al, 2011). Nevertheless, as a linkage between genotype and phenotype, the maintenance of expression of a gene that controls a key developmental process would be crucial in generating phenotypic effects (Crews and Pearson, 2009). This expression maintenance, together with the tissue-or organ-specific expression location defined by transor cis-activities, would result in a specific phenotype.…”

Section: Introductionmentioning

confidence: 99%

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Evolution of Double Positive Autoregulatory Feedback Loops in CYCLOIDEA2 Clade Genes Is Associated with the Origin of Floral Zygomorphy

et al. 2012

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Members of the CYCLOIDEA2 (CYC2) clade of the TEOSINTE BRANCHED1, CYCLOIDEA, and PCF transcription factor genes are widely involved in controlling floral zygomorphy, a key innovation in angiosperm evolution, depending on their persistently asymmetric expression in the corresponding floral domains. However, it is unclear how this asymmetric expression is maintained throughout floral development. Selecting Primulina heterotricha as a model, we examined the expression and function of two CYC2 genes, CYC1C and CYC1D. We analyzed the role of their promoters in protein-DNA interactions and transcription activation using electrophoresis mobility shift assays, chromatin immunoprecipitation, and transient gene expression assays. We find that CYC1C and CYC1D positively autoregulate themselves and cross-regulate each other. Our results reveal a double positive autoregulatory feedback loop, evolved for a pair of CYC2 genes to maintain their expression in developing flowers. Further comparative genome analyses, together with the available expression and function data of CYC2 genes in the core eudicots, suggest that this mechanism might have led to the independent origins of floral zygomorphy, which are associated with plant-insect coevolution and the adaptive radiation of angiosperms.

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Section: A Double Positive Autoregulatory Feedback Loop Accounting Fomentioning

confidence: 99%

Section: A Double Positive Autoregulatory Feedback Loop Accounting Fomentioning

confidence: 99%

Section: A Double Positive Autoregulatory Feedback Loop Accounting Fomentioning

confidence: 99%

Section: A Double Positive Autoregulatory Feedback Loop Accounting Fomentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Evolution of Double Positive Autoregulatory Feedback Loops in CYCLOIDEA2 Clade Genes Is Associated with the Origin of Floral Zygomorphy

et al. 2012

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The limb dorsoventral axis: Lmx1b's role in development, pathology, evolution, and regeneration

Castilla‐Ibeas,

Zdral,

Oberg

et al. 2024

Developmental Dynamics

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The limb anatomy displays well‐defined dorsal and ventral compartments, housing extensor, and flexor muscles, which play a crucial role in facilitating limb locomotion and manipulation. Despite its importance, the study of limb dorsoventral patterning has been relatively neglected compared to the other two axes leaving many crucial questions about the genes and developmental processes implicated unanswered. This review offers a thorough overview of the current understanding of limb dorsoventral patterning, synthesizing classical literature with recent research. It covers the specification of dorsal fate in the limb mesoderm and its subsequent translation into dorsal morphologies—a process directed by the transcription factor Lmx1b. We also discuss the potential role of dorsoventral patterning in the evolution of paired appendages and delve into the involvement of LMX1B in Nail‐Patella syndrome, discussing the molecular and genetic aspects underlying this condition. Finally, the potential role of dorsoventral polarity in digit tip regeneration, a prominent instance of multi‐tissue regeneration in mammals is also considered. We anticipate that this review will renew interest in a process that is critical to limb function and evolutionary adaptations but has nonetheless been overlooked.

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Master Regulatory Transcription Factors in Plant Development: A Blooming Perspective

Kaufmann

Airoldi

2018

Methods in Molecular Biology

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Transcription factors that trigger major developmental decisions in plants and animals are termed "master regulators". Such master regulators are classically seen as acting on the top of a regulatory hierarchy that determines a complete developmental program, and they usually encode transcription factors. Here, we introduce master regulators of flowering time and flower development as examples to show how analysis of molecular interactions and gene-regulatory networks in plants has changed our view on the molecular mechanisms by which these factors control developmental processes. A picture has emerged that emphasizes a complex combinatorial interplay in determining cell-type transcriptional programs, and a high level of feedback control. The expression of master regulators themselves is usually regulated by multiple factors integrating environmental and endogenous spatiotemporal cues. Master regulatory transcription factors regulate gene expression by different mechanisms, including modifications in chromatin status in the bound regions. A poorly understood phenomenon is how developmental master regulators exert functions in different cell- and organ types. This is especially relevant for those factors that have important functions in several developmental processes.

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Transcriptional autoregulation in development

Cited by 99 publications

References 8 publications

Evolution of Double Positive Autoregulatory Feedback Loops in CYCLOIDEA2 Clade Genes Is Associated with the Origin of Floral Zygomorphy

Evolution of Double Positive Autoregulatory Feedback Loops in CYCLOIDEA2 Clade Genes Is Associated with the Origin of Floral Zygomorphy

The limb dorsoventral axis: Lmx1b's role in development, pathology, evolution, and regeneration

Master Regulatory Transcription Factors in Plant Development: A Blooming Perspective

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