“…4). In line with this, combined action and regulation of the biotransformation enzymes and ABC transporters has been reported in humans (Olinga et al, 2008) and several fish species (e.g., killifish, red mullet, and Nile tilapia) (Christine Paetzold et al, 2009;Della Torre et al, 2010;Costa et al, 2012). Moreover, Vollrath et al (2006) have described Nrf2-mediated co-regulation of MRP2 (ABCC2), GST, and GCLC.…”