Transcriptional and hormonal profiling of Fusarium graminearum-infected wheat reveals an association between auxin and susceptibility

Brauer, Elizabeth K.; Rocheleau, Hélène; Balcerzak, Margaret; Pan, Youlian; Fauteux, François; Liu, Ziying; Wang, Li; Zheng, W J; Ouellet, Thérèse

doi:10.1016/j.pmpp.2019.04.006

Cited by 31 publications

(25 citation statements)

References 41 publications

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“…Auxin has also been reported to increase the severity of rust infection in wheat (Artemenko et al, 1980;Yin et al, 2014). A study has demonstrated that auxin plays a negative role in FHB, which was determined by combining transcriptional and hormonal profiling (Brauer et al, 2019). These reports suggest that auxin can negatively regulate plant responses to various diseases; they are consistent with our findings in the present study wherein we found that auxin increases wheat susceptibility to FHB.…”

Section: Discussionsupporting

confidence: 92%

Integrated metabolo‐transcriptomics and functional characterization reveals that the wheat auxin receptor TIR1 negatively regulates defense against Fusarium graminearum

Zhao

et al. 2020

JIPB

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Fusarium head blight (FHB) caused by Fusarium graminearum Schwabe (teleomorph Gibberella zeae (Schw.) Perch) results in large yield losses in annual global wheat production. Although studies have identified a number of wheat FHB resistance genes, a deeper understanding of the mechanisms underlying host plant resistance to F. graminearum is required for the control of FHB. Here, an integrated metabolomics and transcriptomics analysis of infected wheat plants (Triticum aestivum L.

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Section: Discussionsupporting

confidence: 92%

Integrated metabolo‐transcriptomics and functional characterization reveals that the wheat auxin receptor TIR1 negatively regulates defense against Fusarium graminearum

Zhao

et al. 2020

JIPB

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“…If most studies have focused on the genetic determinants of wheat resistance to FHB so far, an interesting alternative is to consider the molecular and the physiological processes that make the host plant susceptible to F. graminearum. An extensive literature dealing with largescale analyses has already shown that, compared to resistant cultivars, the most susceptible ones are characterized by a specific deregulation of genes involved in a wide range of molecular processes (e.g., transcription factors, enzymes involved in primary and secondary metabolism, and defense-related genes), suggesting the intricate participation of a wealth of potential susceptibility factors (Ding et al, 2011;Gottwald et al, 2012;Erayman et al, 2015;Wang et al, 2018;Brauer et al, 2019).…”

Section: Fhb Infection Process: Is Susceptibility Behind the Mirror?mentioning

confidence: 99%

“…A virus-induced gene silencing approach demonstrated a role of the wheat ABA receptor Ta_PYL4AS_A (Figure 1), and its close homologs, in mediating FHB susceptibility and in decreasing mycotoxin accumulation (Gordon et al, 2016). Likewise, transcriptional and hormonal profiling showed that wheat genes involved in auxin biosynthesis were highly up-regulated, along with auxin accumulation, in the susceptible cultivars during the F. graminearum infection process as compared to the resistant ones (Biselli et al, 2018;Wang et al, 2018;Brauer et al, 2019). Salicylic and jasmonic acids are also widely described for their role in modulating FHB responses and in discriminating resistant vs. susceptible cultivars as well (Ding et al, 2011;Gottwald et al, 2012;Sun et al, 2016;Wang et al, 2018).…”

Section: Role Of Phytohormones In Fhb Developmentmentioning

confidence: 99%

Searching for FHB Resistances in Bread Wheat: Susceptibility at the Crossroad

et al. 2020

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Fusarium head blight (FHB), primarily caused by Fusarium graminearum, is one of the most devastating fungal wheat diseases. During the past decades, many efforts have been deployed to dissect FHB resistance, investigating both the wheat responses to infection and, more recently, the fungal determinants of pathogenicity. Although no total resistance has been identified so far, they demonstrated that some plant functions and the expression of specific genes are needed to promote FHB. Associated with the increasing list of F. graminearum effectors able to divert plant molecular processes, this fact strongly argues for a functional link between susceptibility-related factors and the fate of this disease in wheat. In this review, we gather more recent data concerning the involvement of plant and fungal genes and the functions and mechanisms in the development of FHB susceptibility, and we discuss the possibility to use them to diversify the current sources of FHB resistance.

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“…Elevated levels of reactive oxygen species (ROS) induced during stress responses in A. thaliana affect AtMIN7-dependent PIN endocytic recycling resulting in increased accumulation of auxin in the affected tissues (Zwiewka et al, 2019). A recent study demonstrated that higher levels of auxin are accumulated during F. graminearum infection in a susceptible wheat cultivar Roblin compared to the moderately resistant cultivars Wuhan 1 and Nyubai, indicating that auxin may promote susceptibility to this fungal pathogen (Brauer et al, 2019). Moreover, analysis of the recently released transcriptome data indicated that wheat homologs of AtMin7 and PIN genes are down-regulated during F. graminearum infection whereas numerous transcripts of genes belonging to auxin pathway are being up-regulated (Pan et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

The vesicular trafficking system component MIN7 is required for minimizing Fusarium graminearum infection

Wood

Panwar

Grimwade-Mann

et al. 2020

Preprint

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Plants have developed intricate defense mechanisms, referred to as innate immunity, to defend themselves against a wide range of pathogens. Plants often respond rapidly to pathogen attack by the synthesis and delivery of various antimicrobial compounds, proteins and small RNA in membrane vesicles to the primary infection sites. Much of the evidence regarding the importance of vesicular trafficking in plant-pathogen interactions comes from the studies involving model plants whereas this process is relatively understudied in crop plants. Here we assessed whether the vesicular trafficking system components previously implicated in immunity in Arabidopsis thaliana play a role in the interaction with Fusarium graminearum, a fungal pathogen notoriously famous for its ability to cause Fusarium head blight (FHB) disease in wheat. Among the analyzed vesicular trafficking mutants, two independent T-DNA insertion mutants in the AtMin7 gene displayed a markedly enhanced susceptibility to F. graminearum. Earlier studies identified this gene, encoding an ARF-GEF protein, as a target for the HopM1 effector of the bacterial pathogen Pseudomonas syringae pv. tomato, which destabilizes AtMIN7 leading to its degradation and weakening host defenses. To test whether this key vesicular trafficking component may also contribute to defense in crop plants, we identified the candidate TaMin7 genes in wheat and knocked-down their expression through Virus induced gene silencing. Wheat plants in which TaMIN7 were silenced displayed significantly more FHB disease. This suggests that disruption of MIN7 function in both model and crop plants compromises the trafficking of innate immunity signals or products resulting in hyper-susceptibility to various pathogens.One sentence summaryDisruption of an ARF-GEF protein encoding gene AtMin7 in Arabidopsis thaliana and silencing of the orthologous gene in wheat result in hyper susceptibility to the fungal pathogen Fusarium graminearum.

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Transcriptional and hormonal profiling of Fusarium graminearum-infected wheat reveals an association between auxin and susceptibility

Cited by 31 publications

References 41 publications

Integrated metabolo‐transcriptomics and functional characterization reveals that the wheat auxin receptor TIR1 negatively regulates defense against Fusarium graminearum

Integrated metabolo‐transcriptomics and functional characterization reveals that the wheat auxin receptor TIR1 negatively regulates defense against Fusarium graminearum

Searching for FHB Resistances in Bread Wheat: Susceptibility at the Crossroad

The vesicular trafficking system component MIN7 is required for minimizing Fusarium graminearum infection

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