Transcriptional and Genomic Targets of Neural Stem Cells for Functional Recovery after Hemorrhagic Stroke

Abstract

Hemorrhagic stroke is a life-threatening disease characterized by a sudden rupture of cerebral blood vessels, and it is widely believed that neural cell death occurs after exposure to blood metabolites or subsequently damaged cells. Neural stem cells (NSCs), which maintain neurogenesis and are found in subgranular zone and subventricular zone, are thought to be an endogenous neuroprotective mechanism for these brain injuries. However, due to the complexity of NSCs and their microenvironment, current strategies cannot satisfactorily enhance functional recovery after hemorrhagic stroke. It is well known that transcriptional and genomic pathways play important roles in ensuring the normal functions of NSCs, including proliferation, migration, differentiation, and neural reconnection. Recently, emerging evidence from the use of new technologies such as next-generation sequencing and transcriptome profiling has provided insight into our understanding of genomic function and regulation of NSCs. In the present article, we summarize and present the current data on the control of NSCs at both the transcriptional and genomic levels. Using bioinformatics methods, we sought to predict novel therapeutic targets of endogenous neurogenesis and exogenous NSC transplantation for functional recovery after hemorrhagic stroke, which could also advance our understanding of its pathophysiology.

BMP4/LIF or RA/Forskolin Suppresses the Proliferation of Neural Stem Cells Derived from Adult Monkey Brain

“…Brain injuries such as a traumatic injury, stroke, or other neurodegenerative disorders are life-threatening damage and leading causes of death and disability in the population worldwide, with an extensive range of symptoms and disabilities [ 40 – 42 ]. Brain injury causes neural cell death when the damage occurs and tissue lacks blood oxygen supply.…”

Discovering Haematoma-Stimulated Circuits for Secondary Brain Injury after Intraventricular Haemorrhage by Spatial Transcriptome Analysis

“…In summary, our study not only identified the brain regions affected by secondary neurological dysfunction after IVH [15][16][17] from a 3D perspective but it also has the potential for us to construct corresponding intervention strategies for acute traumatic brain trauma at the molecular and cellular levels in the distant future.…”

Discovering hematoma-stimulated circuits for secondary brain injury after intraventricular hemorrhage by spatial transcriptome analysis

“…In summary, our study not only identified the brain regions affected by secondary neurological dysfunction after IVH stimulation from a 3D perspective but also allows for the further investigation of driving cell types and molecular pathways, which might benefit the construction of translational intervention strategies for secondary brain injuries after IVH at the molecular and cellular levels in the distant future (20)(21)(22). Finally, our study is available via a web service (www.combio-lezhang.online/3dstivh/home).…”