Transcriptional activities of medaka Oryzias latipes peroxisome proliferator-activated receptors and their gene expression profiles at different temperatures

Kondo, Hidehiro; Misaki, Ryohei; Watabe, Shugo

doi:10.1007/s12562-009-0193-y

Cited by 11 publications

(7 citation statements)

References 30 publications

(43 reference statements)

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“…Similarly, using both PPARα isoforms from the torafugu pufferfish for transfections in a goldfish cell line, Kondo et al [ 25 ] also demonstrated the activation of the receptors by fatty acids, Wy-14643, and ETYA and, furthermore, showed a small but significant activation of PPARαb by rosiglitazone. Similar results were also reported for the medaka ( Oryzias latipes ) PPARαa [ 63 ].…”

Section: The Functional Domains Of Fpparssupporting

confidence: 88%

The Peroxisome Proliferator-Activated Receptors of Ray-Finned Fish: Unique Structures, Elusive Functions

Boukouvala,

Krey

2024

Biomolecules

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The Actinopterygian and specifically the Teleostean peroxisome proliferator-activated receptors (PPARs) present an impressive variability and complexity in their structures, both at the gene and protein levels. These structural differences may also reflect functional divergence from their mammalian homologs, or even between fish species. This review, taking advantage of the data generated from the whole-genome sequencing of several fish species, highlights the differences in the primary structure of the receptors, while discussing results from the literature pertaining to the functions of fish PPARs and their activation by natural and synthetic compounds.

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Section: The Functional Domains Of Fpparssupporting

confidence: 88%

The Peroxisome Proliferator-Activated Receptors of Ray-Finned Fish: Unique Structures, Elusive Functions

Boukouvala,

Krey

2024

Biomolecules

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“…Nuclear receptors can interact, either directly or indirectly, with epigenetic modifiers that control plastic responses to environmental signals (Legrand et al ., 2019). They can thereby upregulate or downregulate entire transcriptional programmes in response to environmental cues, such as temperature (Kondo et al ., 2009).…”

Section: Signalling Pathwaysmentioning

confidence: 99%

What do warming waters mean for fish physiology and fisheries?

Little

Loughland

Seebacher

2020

Journal of Fish Biology

118

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Environmental signals act primarily on physiological systems, which then influence higher-level functions such as movement patterns and population dynamics. Increases in average temperature and temperature variability associated with global climate change are likely to have strong effects on fish physiology and thereby on populations and fisheries. Here we review the principal mechanisms that transduce temperature signals and the physiological responses to those signals in fish. Temperature has a direct, thermodynamic effect on biochemical reaction rates. Nonetheless, plastic responses to longer-term thermal signals mean that fishes can modulate their acute thermal responses to compensate at least partially for thermodynamic effects. Energetics are particularly relevant for growth and movement, and therefore for fisheries, and temperature can have pronounced effects on energy metabolism. All energy (ATP) production is ultimately linked to mitochondria, and temperature has pronounced effects on mitochondrial efficiency and maximal capacities. Mitochondria are dependent on oxygen as the ultimate electron acceptor so that cardiovascular function and oxygen delivery link environmental inputs with energy metabolism.

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“…It typically induces an increase in mitochondrial volume (Egginton and Sidell, 1989;Johnston, 1982;Tyler and Sidell, 1984), mitochondrial enzyme activity and transcript levels (Battersby and Moyes, 1998;Itoi et al, 2003;Kikuchi et al, 1999;Kondo et al, 2010). We focused on COX because of its critical role in oxidative phosphorylation (OXPHOS) (Villani and Attardi, 2000), the wealth of knowledge about the function of its individual subunits, and the distinctions between the repertoire of isoforms in fish and mammals (Little et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Coordination of cytochrome c oxidase gene expression in the remodelling of skeletal muscle

Duggan

Kocha

Monk

et al. 2011

Journal of Experimental Biology

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SUMMARYMany fish species respond to low temperature by inducing mitochondrial biogenesis, reflected in an increase in activity of the mitochondrial enzyme cytochrome c oxidase (COX). COX is composed of 13 subunits, three encoded by mitochondrial (mt)DNA and 10 encoded by nuclear genes. We used real-time PCR to measure mRNA levels for the 10 nuclear-encoded genes that are highly expressed in muscle. We measured mRNA levels in white muscle of three minnow species, each at two temperatures: zebrafish (Danio rerio) acclimated to 11 and 30°C, goldfish (Carassius auratus) acclimated to 4 and 35°C, and northern redbelly dace (Chrosomus eos) collected in winter and summer. We hypothesized that temperature-induced changes in COX activity would be paralleled by COX nuclear-encoded subunit transcript abundance. However, we found mRNA for COX subunits showed pronounced differences in thermal responses. Though zebrafish COX activity did not change in the cold, the transcript levels of four subunits decreased significantly (COX5A1, 60% decrease; COX6A2, 70% decrease; COX6C, 50% decrease; COX7B, 55% decrease). Treatments induced changes in COX activity in both dace (2.9 times in winter fish) and goldfish (2.5 times in cold fish), but the response in transcript levels was highly variable. Some subunits failed to increase in one (goldfish COX7A2, dace COX6A2) or both (COX7B, COX6B2) species. Other transcripts increased 1.7-100 times. The most cold-responsive subunits were COX4-1 (7 and 21.3 times higher in dace and goldfish, respectively), COX5A1 (13.9 and 5 times higher), COX6B1 (6 and 10 times higher), COX6C (11 and 4 times higher) and COX7C (13.3 and 100 times higher). The subunits that most closely paralleled COX increases in the cold were COX5B2 (dace 2.5 times, goldfish 1.7 times) and COX6A2 (dace 4.1 times, goldfish 1.7 times). Collectively, these studies suggest that COX gene expression is not tightly coordinated during cold-induced mitochondrial remodelling in fish muscle. Further, they caution against arguments about the importance of transcriptional regulation based on measurement of mRNA levels of select subunits of multimeric proteins.

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Transcriptional activities of medaka Oryzias latipes peroxisome proliferator-activated receptors and their gene expression profiles at different temperatures

Cited by 11 publications

References 30 publications

The Peroxisome Proliferator-Activated Receptors of Ray-Finned Fish: Unique Structures, Elusive Functions

The Peroxisome Proliferator-Activated Receptors of Ray-Finned Fish: Unique Structures, Elusive Functions

What do warming waters mean for fish physiology and fisheries?

Coordination of cytochrome c oxidase gene expression in the remodelling of skeletal muscle

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