Transcription Repressor HANABA TARANU Controls Flower Development by Integrating the Actions of Multiple Hormones, Floral Organ Specification Genes, and GATA3 Family Genes in<i>Arabidopsis</i>

Zhang, Xiaolan; Zhou, Yun; Ding, Lian; Wu, Zhigang; Liu, Renyi; Meyerowitz, Elliot M.

doi:10.1105/tpc.112.107854

Cited by 125 publications

(133 citation statements)

References 66 publications

Supporting

Mentioning

128

Contrasting

Order By: Relevance

“…We analyzed these B-GATAs also because both AtGATA23 and AtGATA19 (HANL2) had previously been implicated in specific biological processes. AtGATA23 is an early marker gene for lateral root initiation, and AtGATA18/HAN together with AtGATA19/ HANL2 has a described role in flower development (Zhao et al, 2004;De Rybel et al, 2010;Zhang et al, 2013). While our attempts failed to generate overexpression lines for the better studied HAN, we were successful in generating overexpression lines for AtGATA19/HANL2.…”

Section: Atgata23 and Atgata19 Are Distinct From Llm Domain-containinmentioning

confidence: 86%

“…HAN has an additional role in the establishment of cotyledon identity during embryogenesis, a defect that may result from the interference of HAN with the auxin transport machinery (Nawy et al, 2010;Kanei et al, 2012). Overexpression of HAN negatively interferes with the expression of a gene closely related to HAN, HAN-LIKE2 (HANL2; AtGATA19), as well as with the expression of GNC and GNL (Zhang et al, 2013). This suggested that the gain of HAN function might be compensated by the down-regulation of potentially functionally redundant B-GATAs.…”

mentioning

confidence: 99%

“…This suggested that the gain of HAN function might be compensated by the down-regulation of potentially functionally redundant B-GATAs. Further evidence for an interplay of HAN with GNC and GNL comes from the observation that the proteins interact in the yeast (Saccharomyces cerevisiae) two-hybrid system (Zhang et al, 2013). Finally, AtGATA23 is specifically expressed before the first asymmetric division in xylem pole pericycle cells, where it regulates lateral root founder cell specification and root branching patterns (De Rybel et al, 2010).…”

mentioning

confidence: 99%

See 2 more Smart Citations

Functional Diversification within the Family of B-GATA Transcription Factors through the Leucine-Leucine-Methionine Domain

et al. 2014

View full text Add to dashboard Cite

The transcription of the Arabidopsis (Arabidopsis thaliana) GATA transcription factors GATA, NITRATE-INDUCIBLE, CARBON METABOLISM-INVOLVED (GNC) and GNC-LIKE (GNL)/CYTOKININ-RESPONSIVE GATA FACTOR1 is controlled by several growth regulatory signals including light and the phytohormones auxin, cytokinin, and gibberellin. To date, GNC and GNL have been attributed functions in the control of germination, greening, flowering time, floral development, senescence, and floral organ abscission. GNC and GNL belong to the 11-member family of B-class GATA transcription factors that are characterized to date solely by their high sequence conservation within the GATA DNA-binding domain. The degree of functional conservation among the various B-class GATA family members is not understood. Here, we identify and examine B-class GATAs from Arabidopsis, tomato (Solanum lycopersicon), Brachypodium (Brachypodium distachyon), and barley (Hordeum vulgare). We find that B-class GATAs from these four species can be subdivided based on their short or long N termini and the presence of the 13-amino acid C-terminal leucine-leucinemethionine (LLM) domain with the conserved motif LLM. Through overexpression analyses and by complementation of a gnc gnl double mutant, we provide evidence that the length of the N terminus may not allow distinguishing between the different B-class GATAs at the functional level. In turn, we find that the presence and absence of the LLM domain in the overexpressors has differential effects on hypocotyl elongation, leaf shape, and petiole length, as well as on gene expression. Thus, our analyses identify the LLM domain as an evolutionarily conserved domain that determines B-class GATA factor identity and provides a further subclassification criterion for this transcription factor family.

show abstract

Section: Atgata23 and Atgata19 Are Distinct From Llm Domain-containinmentioning

confidence: 86%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Functional Diversification within the Family of B-GATA Transcription Factors through the Leucine-Leucine-Methionine Domain

et al. 2014

View full text Add to dashboard Cite

show abstract

“…The combination of HAN-BD and HAN-AD was used as positive control (Zhang et al, 2013). All constructs were confirmed by sequencing and then transformed into yeast strain AH109.…”

Section: Yeast Two-hybrid Assaymentioning

confidence: 99%

“…Female flower buds from greenhouse-grown cucumber line 3407 were fixed, embedded, sectioned, and hybridized with digoxigenin-labeled probes as described previously (Zhang et al, 2013). Digoxigenin-labeled sense and antisense RNA probes were PCR amplified with T7 and SP6 RNA polymerases (Roche) using gene-specific primers (Supplemental Table S1).…”

Section: In Situ Hybridizationmentioning

confidence: 99%

CsTTG1 Encodes a WD-repeat Protein That Regulates Fruit Wart Formation in Cucumis sativus through Interaction with the Homeodomain-leucine Zipper I Protein Mict

et al. 2016

View full text Add to dashboard Cite

The cucumber (Cucumis sativus) fruit is covered with bloom trichomes and warts (composed of spines and tubercules), which have an important impact on the commercial value of the crop. However, little is known about the regulatory mechanism underlying their formation. Here, we reported that the cucumber WD-repeat homolog CsTTG1, which is localized in the nucleus and cytomembrane, plays an important role in the formation of cucumber fruit bloom trichomes and warts. Functional characterization of CsTTG1 revealed that it is mainly expressed in the epidermis of cucumber ovary and that its overexpression in cucumber alters the density of fruit bloom trichomes and spines, thereby promoting the warty fruit trait. Conversely, silencing CsTTG1 expression inhibits the initiation of fruit spines. Molecular and genetic analyses showed that CsTTG1 acts in parallel to Mict/CsGL1, a key trichome formation factor, to regulate the initiation of fruit trichomes, including fruit bloom trichomes and spines, and that the further differentiation of fruit spines and formation of tubercules regulated by CsTTG1 is dependent on Mict. Using yeast two-hybrid assay and bimolecular fluorescence complementation assay, we determined that CsTTG1 directly interacts with Mict. Collectively, our results indicate that CsTTG1 is an important component of the molecular network that regulates fruit bloom trichome and wart formation in cucumber.

show abstract

Genome‐wide binding analysis of AtGNC and AtCGA1 demonstrates their cross‐regulation and common and specific functions

Casaretto

et al. 2017

Plant Direct

View full text Add to dashboard Cite

GATA transcription factors are involved in multiple processes in plant growth and development. Two GATA factors, NITRATE-INDUCIBLE, CARBON METABOLISM-INVOLVED (GNC) and CYTOKININ-RESPONSIVE GATA FACTOR 1 (CGA1, also named GNL), are important regulators in greening, flowering, senescence, and hormone signaling. However, their direct target genes related to these biological processes are poorly characterized. Here, GNC and CGA1 are shown to be transcription activators and by using chromatin immunoprecipitation sequencing (ChIP-seq), 1475 and 638 genes are identified to be associated with GNC and CGA1 binding, respectively.Enrichment of diverse motifs in the peak binding regions for GNC and CGA1 suggests the possibility that these two transcription factors also interact with other transcription factors and in addition genes coding for DNA-binding proteins are highly enriched among GNC-and CGA1-associated genes. Despite the fact that these two GATA factors are known to share a large portion of co-expressed genes, our analysis revealed a low percentage of overlapping binding-associated genes for these two homologues. This suggests a possible cross-regulation between these, which is verified using ChIP-qPCR. The common and specific biological processes regulated by GNC and CGA1 also support this notion. Functional analysis of the binding-associated genes revealed that those encoding transcription factors, E3 ligase, as well as genes with roles in plant development are highly enriched, indicating that GNC and CGA1 mediate complex genetic networks in regulating different aspects of plant growth and development. variance from what has been described in animals, plant GATA transcription factors preferentially recognize and bind GATC rather than the GATA motif, and the two bases in the middle (AT) are more conserved than the flanking sequence of the binding core across the GATA family (Weirauch et al., 2014).--

show abstract

Transcription Repressor HANABA TARANU Controls Flower Development by Integrating the Actions of Multiple Hormones, Floral Organ Specification Genes, and GATA3 Family Genes inArabidopsis

Cited by 125 publications

References 66 publications

Functional Diversification within the Family of B-GATA Transcription Factors through the Leucine-Leucine-Methionine Domain

Functional Diversification within the Family of B-GATA Transcription Factors through the Leucine-Leucine-Methionine Domain

CsTTG1 Encodes a WD-repeat Protein That Regulates Fruit Wart Formation in Cucumis sativus through Interaction with the Homeodomain-leucine Zipper I Protein Mict

Genome‐wide binding analysis of AtGNC and AtCGA1 demonstrates their cross‐regulation and common and specific functions

Contact Info

Product

Resources

About