Abstract:Objectives Human phospholipid scramblase 1 (hPLSCR1) is a multifunctional protein so it is vital to understand the regulation of its expression and transcription factors play critical role in regulating any gene.Results The transcription factor (TF) prediction tool ConSite identified one S-SOX5 binding site on the promoter region of hPLSCR1. Luciferase assays determined the increase in hPLSCR1 promoter activity with the increase in S-SOX5 concentration in a dose dependent manner. The deletion and the site-dire… Show more
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