Transcription of Message for Tumor Necrosis Factor-alpha by Lacrimal Gland is Regulated by Corneal Wounding

Human Tear Fluid PDGF-BB, TNF-α and TGF-β1 vs Corneal Haze and Regeneration of Corneal Epithelium and Subbasal Nerve Plexus after PRK

“…All tear¯uid samples were collected with a scaled 5 or 25 ml ®re-polished microcapillary tube as previously described (van Setten et al, 1989). Special attention was paid not to irritate the cornea or conjunctiva.…”

“…in increased lacrimal gland mRNA levels for TNF-a, HGF, KGF and EGF (Thompson and Beuerman, 1992;Thompson et al, 1994;Wilson, Liang and Kim, 1999). Whether PRK wound induces cytokine production in the human lacrimal gland is not known.…”

Increased release of tumour necrosis factor-alpha in human tear fluid after excimer laser induced corneal wound

“…On the other hand, in normal lacrimal gland TNF-α mRNA has been demonstrated in both acinar cells and macrophages. Moreover, expression of TNF-α is enhanced after corneal wounding 6. TNF-α is also a potential factor contributing to scar formation 7 and, hence, development of postoperative haze.…”

A Time Course Microarray Study of Gene Expression in the Mouse Lacrimal Gland after Acute Corneal Trauma

“…12,13 Tumor necrosis factor (TNF)-␣ mRNA in the rabbit lacrimal gland was upregulated by corneal wounding. 14 Therefore, it appears that regulation of lacrimal gland gene expression in response to the corneal injury is involved in the creation of dry eye syndrome through partial denervation, overstimulation, or both. However, we have known little about how many genes and what specific genes in the lacrimal gland are altered by corneal injury besides the genes just listed.…”