1998
DOI: 10.1038/2413
|View full text |Cite
|
Sign up to set email alerts
|

Transcription of IAP endogenous retroviruses is constrained by cytosine methylation

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1

Citation Types

32
712
2
7

Year Published

2000
2000
2007
2007

Publication Types

Select...
6
2

Relationship

0
8

Authors

Journals

citations
Cited by 994 publications
(753 citation statements)
references
References 9 publications
32
712
2
7
Order By: Relevance
“…This was further supported by sequence data obtained from the IAP-Notch1 hybrid transcripts: all cloned hybrids varied in their IAP portion suggesting that they originate from different IAP elements (Supplementary Figure 3). IAP expression is suppressed by DNA methylation and was found to be significantly elevated in demethylated ES cells and embryos (Walsh et al, 1998). Mice carrying the hypomorphic allele Dnmt1 Chip/À exhibit genomewide DNA hypomethylation in all tissues and throughout embryonic development ), yet we could not find any significant increase in IAP expression in a variety of tissues from the preleukemic Dnmt1 Chip/À mice or in MOV-induced lymphomas (Figure 4).…”
mentioning
confidence: 75%
“…This was further supported by sequence data obtained from the IAP-Notch1 hybrid transcripts: all cloned hybrids varied in their IAP portion suggesting that they originate from different IAP elements (Supplementary Figure 3). IAP expression is suppressed by DNA methylation and was found to be significantly elevated in demethylated ES cells and embryos (Walsh et al, 1998). Mice carrying the hypomorphic allele Dnmt1 Chip/À exhibit genomewide DNA hypomethylation in all tissues and throughout embryonic development ), yet we could not find any significant increase in IAP expression in a variety of tissues from the preleukemic Dnmt1 Chip/À mice or in MOV-induced lymphomas (Figure 4).…”
mentioning
confidence: 75%
“…To investigate whether global methylation was affected in mutant mice, we examined the methylation of IAP elements (Walsh et al, 1998). Genomic DNA from forebrain, cerebellum, and heart samples from adult mice were digested with HpaII, which recognizes 5ЈCCGG3Ј targets and is sensitive to methylation at the internal cytosine.…”
Section: Cre1 Mutant Micementioning
confidence: 99%
“…Methylation analysis. A: Methylation at intracisternal A particle elements (Walsh et al, 1998). Southern blot of genomic DNA from heterozygous (H, Dnmt3a 2lox/ϩ ;Nes-Cre1) and mutant (M, Dnmt3a 2lox/1lox ;Nes-Cre1) mice digested with HpaII, a methylation sensitive enzyme that cleaves at CCGGs.…”
Section: Dnmt3a/nes-cre1 Mutant Mice Appear Normalmentioning
confidence: 99%
See 1 more Smart Citation
“…Long repeats including LINE-1 elements are normally heavily DNA-methylated (Woodcock et al, 1988;Crowther et al, 1991;Woodcock et al, 1997), a feature of heterochromatin. DNA methylation (and heterochromatin in general) has been reported to suppress homologous recombination (Pàldi et al, 1995;Maloisel and Rossignol, 1998;Schnable et al, 1998;Fu et al, 2002;Yao et al, 2002;Yamada et al, 2004;Myers et al, 2005) as well as transposition (Yoder et al, 1997;Walsh et al, 1998;Hirochika et al, 2000;Robertson, 2001;Bird, 2002;Kato et al, 2003). Accordingly, reports of deletions caused by homologous recombination between LINE-1 elements are rare (Segal et al, 1999) except in cancers (Florl and Schulz, 2003) where LINE-1 elements are frequently hypomethylated (Santourlidis et al, 1999;Takai et al, 2000;Ehrlich, 2002;Carnell and Goodman, 2003;Florl et al, 2004;Roman-Gomez et al, 2005).…”
Section: Non-random Repeat Distributions Via Natural Selectionmentioning
confidence: 99%