Transcription factors involved in stem cell maintenance are downstream of Slug/Snail2 and repressed by TGF-β in bronchial basal stem/progenitor cells from COPD
Abstract:22Objectives: Patients with Chronic Obstructive Pulmonary Disease (COPD) have a bronchial 23 epithelium with many anomalies and basal/progenitor cells showing a decrease of self-renewal 24 and differentiation potential. The objective of this study was to identify deregulations in the 25 genetic program of COPD bronchial progenitors that could account for their exhaustion. The 26 transcription factor Slug/Snail2 is highly expressed in bronchial progenitors and we aimed at 27 identifying genes downstream of Slug… Show more
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