Transcription factor PBX4 regulates limb development and haematopoiesis in mice
Yan Ning,
Shuguang Duo,
Xiwen Lin
et al.
Abstract:The mammalian Pre‐B cell leukaemia transcription factors 1–4 (PBX1‐4) constitutes the PBC class of the homeodomain (HD)‐containing proteins, which play important roles in diverse developmental processes. The functions and the underlying molecular mechanisms of PBX1‐3 but not PBX4 have been extensively studied, and they have been reported to direct essential morphogenetic processes and organogenesis. In the present study, we generated knockin mice of FLAG‐tagged PBX4 and the Pbx4 knockout (KO) mice and carried … Show more
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