Transcription factor EB reprograms branched‐chain amino acid metabolism and promotes pancreatic cancer progression via transcriptional regulation of BCAT1
Ting Wang,
Qiangsheng Hu,
Borui Li
et al.
Abstract:Pancreatic cancer cells have a much higher metabolic demand than that of normal cells. However, the abundant interstitium and lack of blood supply determine the lack of nutrients in the tumour microenvironment. Although pancreatic cancer has been reported to supply extra metabolic demand for proliferation through autophagy and other means, the specific regulatory mechanisms have not yet been elucidated. In this study, we focused on transcription factor EB (TFEB), a key factor in the regulation of autophagy, to… Show more
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