Transcription factor NF-κB as mediator of sulfur mustard induced damage of the skin

Rebholz, Bernd; Kehe, Kai; Rupec, Rudolf A.

doi:10.1016/j.tox.2006.04.008

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“…Studies have shown that abnormal stimulation in the body accelerates the phosphorylation of I κ B protein, which activates NF- κ B to further increase the release of proinflammatory cytokines such as TNF- α , IL-6, IL-12, COX-2, and iNOS [ 27 , 28 ]. Many studies have shown that the NF- κ B signaling pathway is closely related to the inflammatory response in the body, and NF- κ B signaling dysfunction is often seen during skin injury [ 29 , 30 ].…”

Section: Discussionmentioning

confidence: 99%

Cloves Regulate Na⁺‐K⁺‐ATPase to Exert Antioxidant Effect and Inhibit UVB Light‐Induced Skin Damage in Mice

Gao

Luo

Zhao

2021

Oxidative Medicine and Cellular Longevity

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The purpose of this study was to observe the effect of cloves (Syzygium aromaticum (L.) Merr. & L.M. Perry) on the mouse skin using a UVB-induced skin injury mouse model. The serum, liver, and skin indexes of mice were determined by kits, H&E tissue staining, and qPCR assay. The compound composition of cloves was determined by HPLC. The results showed that cloves increased the activity of Na+-K+-ATPase in the skin and then maintained the sodium and potassium pump in the damaged skin muscle membrane. Cloves alleviated the oxidative stress injury induced by UVB irradiation by normalizing the related oxidative stress indexes (T-SOD, CAT, AGEs, and H2O2) in serum and skin. Inhibition of the proinflammatory cytokines TNF-α, IL-1β, and IL-6 and increased activation of anti-inflammatory cytokines IL-4 and IL-10 occurred after treatment with cloves, which ultimately reduced the inflammatory damage to the body. Further results showed that cloves upregulate SOD1, SOD2, CAT, GSH, IL-10, IκB-α, AMPK, SIRT1, LKB1, PGC-1α, APPL1, and FoxO1 and downregulate NF-κB p65, TNF-α, IL-6, and mTOR mRNA expression in the skin tissues of UVB-damaged mice. The results of composition analysis showed that the five most abundant compounds in cloves are rutin, isoquercitrin, ferulic acid, dihydroquercetin, and quercitrin. Cloves regulate the skin sarcomembrane Na+-K+-ATPase through these five compounds, and because they regulate the oxidation, inflammation, and ATP energy consumption of the body, they subsequently protect the skin from UVB damage.

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Section: Discussionmentioning

confidence: 99%

Cloves Regulate Na⁺‐K⁺‐ATPase to Exert Antioxidant Effect and Inhibit UVB Light‐Induced Skin Damage in Mice

Gao

Luo

Zhao

2021

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

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Transcription factor NF-κB as mediator of sulfur mustard induced damage of the skin

Cited by 1 publication

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Cloves Regulate Na⁺‐K⁺‐ATPase to Exert Antioxidant Effect and Inhibit UVB Light‐Induced Skin Damage in Mice

Cloves Regulate Na⁺‐K⁺‐ATPase to Exert Antioxidant Effect and Inhibit UVB Light‐Induced Skin Damage in Mice

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Transcription factor NF-κB as mediator of sulfur mustard induced damage of the skin

Cited by 1 publication

References 0 publications

Cloves Regulate Na+‐K+‐ATPase to Exert Antioxidant Effect and Inhibit UVB Light‐Induced Skin Damage in Mice

Cloves Regulate Na+‐K+‐ATPase to Exert Antioxidant Effect and Inhibit UVB Light‐Induced Skin Damage in Mice

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About

Cloves Regulate Na⁺‐K⁺‐ATPase to Exert Antioxidant Effect and Inhibit UVB Light‐Induced Skin Damage in Mice

Cloves Regulate Na⁺‐K⁺‐ATPase to Exert Antioxidant Effect and Inhibit UVB Light‐Induced Skin Damage in Mice