Transcription Factor NF-κ B: Function, Structure, Regulation, Pathways, and Applications

Cheong, Raymond; Levchenko, Andre

doi:10.1002/3527600906.mcb.200500006

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The Nf-κb Pathway1

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2008

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“…Nuclear factor-kappaB (NF-κB) is a conserved transcription factor that has been a paradigm for gene regulation for more than 20 years [1]. It is the central mediator of inflammation and also has roles in apoptosis, adaptive immunity, immune system development, and neurological memory [2]. NF-κB is implicated in a myriad of common diseases especially those with inflammatory or autoimmune components like septic shock, cancer, arthritis, asthma, diabetes, and atherosclerosis to name a few [3].…”

Section: The Nf-κb Pathwaymentioning

confidence: 99%

Wires in the soup: quantitative models of cell signaling

Cheong

Levchenko

2008

Trends in Cell Biology

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Living cells are capable of extracting information from their environments and mounting appropriate responses to a variety of challenges. The underlying signal transduction networks enabling this response can be quite complex, and so sophisticated computational modeling coupled with precise experimentation is required to unravel them. Although we are still at the beginning of this process, some recent examples of integrative analysis of cell signaling are very encouraging. Quantitative models of signaling pathways (e.g. NF-kappaB) can be gradually constructed through continuous experimental validation, and important lessons can be learnt from such exercises.

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Section: The Nf-κb Pathwaymentioning

confidence: 99%