Transcription factor induction of human oligodendrocyte progenitor fate and differentiation

Wang, Jing; Pol, Suyog; Haberman, Alexa K.; Wang, Chunming; O’Bara, Melanie A.; Sim, Fraser J.

doi:10.1073/pnas.1408295111

Cited by 72 publications

(76 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Sox10 can restrict differentiation of neural precursor cells into the OL lineage, in part by regulating the expression of the Shh signaling pathway (Pozniak et al, 2010). Overexpression of Sox10 alone is sufficient to promote the commitment of neural precursor cells toward the OL lineage to form mature OLs (Wang et al, 2014). …”

Section: Control Of Opc Specification and Plasticity By Intrinsic Facmentioning

confidence: 99%

Oligodendrocyte progenitor programming and reprogramming: Toward myelin regeneration

Juarez

Lü

2016

Brain Research

View full text Add to dashboard Cite

Demyelinating diseases such as multiple sclerosis (MS) are among the most disabling and cost-intensive neurological disorders. The loss of myelin in the central nervous system, produced by oligodendrocytes (OLs), impairs saltatory nerve conduction, leading to motor and cognitive deficits. Immunosuppression therapy has a limited efficacy in MS patients, arguing for a paradigm shift to strategies that target OL lineage cells to achieve myelin repair. The inhibitory microenvironment in MS lesions abrogates the expansion and differentiation of resident OL precursor cells (OPCs) into mature myelin-forming OLs. Recent studies indicate that OPCs display a highly plastic ability to differentiate into alternative cell lineages under certain circumstances. Thus, understanding the mechanisms that maintain and control OPC fate and differentiation into mature OLs in a hostile, non-permissive lesion environment may open new opportunities for regenerative therapies. In this review, we will focus on 1) the plasticity of OPCs in terms of their developmental origins, distribution, and differentiation potentials in the normal and injured brain; 2) recent discoveries of extrinsic and intrinsic factors and small molecule compounds that control OPC specification and differentiation; and 3) therapeutic potential for motivation of neural progenitor cells and reprogramming of differentiated cells into OPCs and their likely impacts on remyelination. OL-based therapies through activating regenerative potentials of OPCs or cell replacement offer exciting opportunities for innovative strategies to promote remyelination and neuroprotection in devastating demyelinating diseases like MS.

show abstract

Section: Control Of Opc Specification and Plasticity By Intrinsic Facmentioning

confidence: 99%

Oligodendrocyte progenitor programming and reprogramming: Toward myelin regeneration

Juarez

Lü

2016

Brain Research

View full text Add to dashboard Cite

show abstract

“…Ascl1 regulates astrocytes and oligodendrocytes by density and distribution in neurodegenerative diseases [46,47]. Under certain conditions, ASH1L can regulate interleukin-6 production.…”

Section: Discussionmentioning

confidence: 99%

Differences of immune disorders between Alzheimer’s disease and breast cancer based on transcriptional regulation

et al. 2017

View full text Add to dashboard Cite

Although chronic inflammation and immune disorders are of great importance to the pathogenesis of both dementia and cancer, the pathophysiological mechanisms are not clearly understood. In recent years, growing epidemiological evidence and meta-analysis data suggest an inverse association between Alzheimer’s disease (AD), which is the most common form of dementia, and cancer. It has been revealed that some common genes and biological processes play opposite roles in AD and cancer; however, the biological immune mechanism for the inverse association is not clearly defined. An unsupervised matrix decomposition two-stage bioinformatics procedure was adopted to investigate the opposite behaviors of the immune response in AD and breast cancer (BC) and to discover the underlying transcriptional regulatory mechanisms. Fast independent component analysis (FastICA) was applied to extract significant genes from AD and BC microarray gene expression data. Based on the extracted data, the shared transcription factors (TFs) from AD and BC were captured. Second, the network component analysis (NCA) algorithm in this study was presented to quantitatively deduce the TF activities and regulatory influences because quantitative dynamic regulatory information for TFs is not available via microarray techniques. Based on the NCA results and reconstructed transcriptional regulatory networks, inverse regulatory processes and some known innate immune responses were described in detail. Many of the shared TFs and their regulatory processes were found to be closely related to the adaptive immune response from dramatically different directions and to play crucial roles in both AD and BC pathogenesis. From the above findings, the opposing cellular behaviors demonstrate an invaluable opportunity to gain insights into the pathogenesis of these two types of diseases and to aid in developing new treatments.

show abstract

“…This protocol has been further optimized by a various groups (Franco et al 2015;Neri et al 2010;. In a number of studies, ectopic overexpression of either Sox10 (C. D. Pozniak et al 2010a;Wang et al 2014), Olig2 (Copray et al 2006;) or both (Liu et al 2007) has been shown to facilitate or even induce NSC differentiation toward oligodendrocyte linage. However, this approach cannot provide immunologically matched cell types for cell therapy due to difficulty of obtaining adult NSCs.…”

Section: Methods For Generation Of Oligodendrocytes Ex Vivomentioning

confidence: 99%

Programming and reprogramming neural cell types using synthetic transcription factors

Matjusaitis¹

2016

IET/SynbiCITE Engineering Biology Conference

View full text Add to dashboard Cite

Transcription factor induction of human oligodendrocyte progenitor fate and differentiation

Cited by 72 publications

References 48 publications

Oligodendrocyte progenitor programming and reprogramming: Toward myelin regeneration

Oligodendrocyte progenitor programming and reprogramming: Toward myelin regeneration

Differences of immune disorders between Alzheimer’s disease and breast cancer based on transcriptional regulation

Programming and reprogramming neural cell types using synthetic transcription factors

Contact Info

Product

Resources

About