Transcription factor HOXB2 upregulates NUSAP1 to promote the proliferation, invasion and migration of nephroblastoma cells via the PI3K/Akt signaling pathway

Lactate-induced activation of tumor-associated fibroblasts and IL-8-mediated macrophage recruitment promote lung cancer progression

“…Lactate has been shown to facilitate the translocation of the microtubule-associated protein NUSAP1 to the nuclei, where it forms transcription complexes with transcription factors, regulating the expression of downstream genes, including LDHA, and establishing a NUSAP1-lactate feedforward loop [ 39 ]. NUSAP1 is acknowledged for its involvement in spindle assembly and chromosome segregation [ 69 ]. This led us to inquire whether lactate also influences the nuclear translocation of NUSAP1, forming a NUSAP1-JUNB transcription complex with JUNB to regulate DESMIN expression.…”

Identification and validation of risk score model based on gene set activity as a diagnostic biomarker for endometriosis

“…These genes are mainly associated with cell cycle regulation and likely play a crucial role in cell proliferation and survival, thereby influencing the occurrence and development of EMS genes. Studies have demonstrated the up-regulated cyclin-dependent kinase 1 (CDK1) in ectopic endometrial tissue, which induces proliferation of endometriosis cells [ 9 ]; The number of lesions in rectosigmoid tissue is proportional to the expression of Topoisomerase II alpha (TOP2A) [ 10 ]; inhibition of Kinesin family member 20A (KIF20A) reduces endometriosis lesions in an endometriosis mouse model [ 11 ]; while no related studies or reports on other core genes in the mechanism of EMS are available, they all play roles in tumor growth regulation: Cyclin A2 (CCNA2) promotes the invasion and migration of non-small cell lung cancer cells [ 12 ]; Cell division cycle 20 (CDC20), as a subunit of the mitotic checkpoint complex (MCC), plays a critical role in anaphase and the exit process from mitosis, the activation of which facilitates tumor progression and stemness in gastric cancer [ 13 ]; NUSAP1 (Nucleolar spindle associated protein 1) contributes to the proliferation, invasion, and migration of nephroblastoma through the PI3K/Akt signaling pathway [ 14 ]; the overexpression of spindle microtubules (ASPM) increases tumor invasiveness [ 15 ]; upregulation of Cyclin B2 (CCNB2) [ 16 ] exacerbates lymphovascular invasion in breast cancer; these findings suggest the potential target therapy value of these core genes that can serve as diagnostic biomarkers for EMS. The abnormal activation of signaling pathways typically induces phenotypic alterations in normal tissues and progression toward malignant features.…”

HOXA9 gene inhibits proliferation and differentiation and promotes apoptosis of bovine preadipocytes

“…It was first discovered as a partial transcript in the fetal liver [15], which is well known for its key role in lineage commitment of hematopoietic cells [16]. It not only plays a role in regulatory of cell proliferation, differentiation, apoptosis, tissue and organ formation and individual growth and development [17][18][19], but also participates in the occurrence and poor prognosis of various malignant tumors in human beings [20][21][22]. Existing reports show that HOXA9 differentially expressed in female abdominal and gluteal subcutaneous adipose tissue, which regulated the deposition of fat in different parts of body [23].…”