“…For example, the transcription of genes that are required for the uptake and transport of cholesterol and for its metabolism into cortisol and aldosterone requires several transcription factors (Miller and Auchus, 2011, Rainey and Nakamura, 2008, Sewer et al, 2007, Sewer et al, 2008), including steroidogenic factor 1 (El-Khairi et al, 2011, Hoivik et al, 2010, Schimmer and White, 2010), nerve growth factor 1B (Bassett et al, 2004, Bassett et al, 2004), members of the specificity protein family (e.g. Sp1, Sp3) (Huang et al, 2005, Lin et al, 2001, Rui et al, 2008), sterol regulatory element binding protein 1 (Ozbay et al, 2006), GATA proteins (Fluck and Miller, 2004, Jimenez et al, 2003, Nakamura et al, 2007), and cAMP response element modulator (Meier and Clark, 2012, Sugawara et al, 2006, Zwermann et al, 2007). Moreover, emerging evidence implicates the need for the assembly of macromolecular protein complexes that facilitate the movement of cholesterol into the inner mitochondrial membrane (Bose et al, 2002, Bose et al, 2008, Liu et al, 2006, Rone et al, 2012) and for regulatory mechanisms that govern the selective transfer of electrons (Miller, 2005).…”