Transcription factor EB promotes rheumatoid arthritis of Sprague–Dawley rats via regulating autophagy

Xu, De Lai; Pan, Jie

doi:10.1007/s13205-021-02710-1

Cited by 4 publications

(2 citation statements)

References 43 publications

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“…In lipophagy, lysosomal lipase is expressed by Transcription factor EB (TFEB), a major transcription factor that regulates the transcription of genes involved in multiple biological pathways and is involved in important cellular functions [ 78 ]. These include autophagy, lysosomal biogenesis, lysosomal exocytosis, lipid metabolism, and mitochondrial biogenesis [ 79 – 81 ]. TFEB is positively correlated with the gene expression changes of autophagy genes and the relative lipidation of autophagy marker LC3.…”

Section: Types Of Selective Autophagy and Their Mechanismsmentioning

confidence: 99%

Selective autophagy in cancer: mechanisms, therapeutic implications, and future perspectives

Liu,

Wu,

Meng

et al. 2024

Mol Cancer

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Eukaryotic cells engage in autophagy, an internal process of self-degradation through lysosomes. Autophagy can be classified as selective or non-selective depending on the way it chooses to degrade substrates. During the process of selective autophagy, damaged and/or redundant organelles like mitochondria, peroxisomes, ribosomes, endoplasmic reticulum (ER), lysosomes, nuclei, proteasomes, and lipid droplets are selectively recycled. Specific cargo is delivered to autophagosomes by specific receptors, isolated and engulfed. Selective autophagy dysfunction is closely linked with cancers, neurodegenerative diseases, metabolic disorders, heart failure, etc. Through reviewing latest research, this review summarized molecular markers and important signaling pathways for selective autophagy, and its significant role in cancers. Moreover, we conducted a comprehensive analysis of small-molecule compounds targeting selective autophagy for their potential application in anti-tumor therapy, elucidating the underlying mechanisms involved. This review aims to supply important scientific references and development directions for the biological mechanisms and drug discovery of anti-tumor targeting selective autophagy in the future.

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Section: Types Of Selective Autophagy and Their Mechanismsmentioning

confidence: 99%

Selective autophagy in cancer: mechanisms, therapeutic implications, and future perspectives

Liu,

Wu,

Meng

et al. 2024

Mol Cancer

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“…Due to its prominent role as an upstream regulator of autophagy and lysosomal function, TFEB might constitute a priority target for the efficient therapeutic intervention of these routes. RNA-based therapeutics are expected to soar after the success of RNA-based vaccines; in this sense, numerous studies indicate TFEB is an effective target for the modulation of autophagy and lysosomal activity to successfully counteract different pathological conditions, including cancer [200][201][202][203][204]. Reflecting the highly contextual role of autophagy in cancer, while TFEB and related factors have frequently been regarded as oncogenes, TFEB can behave as a tumor suppressor, as recently reported for acute myeloid leukemia (AML) [205].…”

Section: Modulating the Autophagolysosomal System In Cancer: Therapeutic Opportunitiesmentioning

confidence: 99%

Autophagy and the Lysosomal System in Cancer

Kumar

Sánchez-Álvarez

Lolo

et al. 2021

Cells

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Autophagy and the lysosomal system, together referred to as the autophagolysosomal system, is a cellular quality control network which maintains cellular health and homeostasis by removing cellular waste including protein aggregates, damaged organelles, and invading pathogens. As such, the autophagolysosomal system has roles in a variety of pathophysiological disorders, including cancer, neurological disorders, immune- and inflammation-related diseases, and metabolic alterations, among others. The autophagolysosomal system is controlled by TFEB, a master transcriptional regulator driving the expression of multiple genes, including autophagoly sosomal components. Importantly, Reactive Oxygen Species (ROS) production and control are key aspects of the physiopathological roles of the autophagolysosomal system, and may hold a key for synergistic therapeutic interventions. In this study, we reviewed our current knowledge on the biology and physiopathology of the autophagolysosomal system, and its potential for therapeutic intervention in cancer.

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Anti-rheumatoid arthritis effects of total saponins from Rhizoma Panacis Majoris on adjuvant-induced arthritis in rats and rheumatoid arthritis fibroblast-like synoviocytes

Ren

Pang

et al. 2023

Phytomedicine

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Transcription factor EB promotes rheumatoid arthritis of Sprague–Dawley rats via regulating autophagy

Cited by 4 publications

References 43 publications

Selective autophagy in cancer: mechanisms, therapeutic implications, and future perspectives

Selective autophagy in cancer: mechanisms, therapeutic implications, and future perspectives

Autophagy and the Lysosomal System in Cancer

Anti-rheumatoid arthritis effects of total saponins from Rhizoma Panacis Majoris on adjuvant-induced arthritis in rats and rheumatoid arthritis fibroblast-like synoviocytes

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