2005
DOI: 10.1007/s00702-005-0325-1
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Transcription factor AP-2 and monoaminergic functions in the central nervous system

Abstract: In the central nervous system, transcription factor AP-2 family is one of the critical regulatory factors for neural gene expression and neuronal development. Several genes in the monoaminergic systems display AP-2 binding sites in regulatory regions. In addition, brainstem levels of transcription factor AP-2alpha and AP-2beta are positively correlated to monoamine measures in rat forebrain, suggesting a regulatory role of AP-2 also in the adult brain. Great changes in psychiatric phenotypes due to genetic fac… Show more

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Cited by 44 publications
(40 citation statements)
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“…These personality features are expressed by the involvement of a pattern of neuronal adaptations induced by central genes such as dopamine or serotonin, which has been consistently associated with ED‐coupled personality dimensions (Gervasini & Gamero‐Villarroel, 2015). Dopaminergic and serotonergic genes in the midbrain have AP‐2 binding sites; therefore it is likely that these transcription factors, aside from its established role during development, can also influence mood and personality in adults through this neurotransmitter system (Damberg, 2005; Damberg et al., 2001). In the same manner, variability in the KCTD15 locus could play its role by altering TFAP2B post‐translational modifications leading to orexigenic signaling and consummatory behavior, as shown in Figure 1.…”
Section: Discussionmentioning
confidence: 99%
“…These personality features are expressed by the involvement of a pattern of neuronal adaptations induced by central genes such as dopamine or serotonin, which has been consistently associated with ED‐coupled personality dimensions (Gervasini & Gamero‐Villarroel, 2015). Dopaminergic and serotonergic genes in the midbrain have AP‐2 binding sites; therefore it is likely that these transcription factors, aside from its established role during development, can also influence mood and personality in adults through this neurotransmitter system (Damberg, 2005; Damberg et al., 2001). In the same manner, variability in the KCTD15 locus could play its role by altering TFAP2B post‐translational modifications leading to orexigenic signaling and consummatory behavior, as shown in Figure 1.…”
Section: Discussionmentioning
confidence: 99%
“…A number of polymorphisms have been found in the proximity of the insertion/deletion locus, such as rs25531, rs25532, rs2020933 and a 17-bp variable tandem repeat in the second intron (STin2) [50,51,52,53], and have been proposed to modulate the functionality of 5-HTTLPR [3]. The rs25531, which is located in the sixth repeat of the 5-HTTLPR outside the deleted segment [3], can co-occur with either the long or short variant of the 5-HTTLPR [9].…”
Section: Discussionmentioning
confidence: 99%
“…: fatty acid amide hydrolase, FAAH), главного фермента деградации эндоканнабиноидов, вовлеченных как в механизмы ад-дикции, так и в регуляцию пищевого поведения, оказался связанным с ожирением, но не с ВЕD [52]. Возможна роль генетических вариантов, связанных с системами регуля-обзоры ции экспрессии генов, прежде всего различных транс-крипционных факторов, например имеются данные о возможной связи гена транскрипционного фактора АР2μ с ВЕD [53].…”
Section: молекулярная генетика веDunclassified