Transcription factor 7-like 2 single nucleotide polymorphisms are associated with lipid profile in the Balinese

Oktavianthi, Sukma; Saraswati, Made Ratna; Suastika, Ketut; Dwipayana, Pande; Sulfianti, Asri; Hayati, Rahma; Trimarsanto, Hidayat; Febinia, Clarissa A.; Sudoyo, Herawati; Malik, Safarina G.

doi:10.1007/s11033-018-4265-x

Cited by 6 publications

(5 citation statements)

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“…Therefore, the significant association between TCF7L2 SNPs with TC might occur due to its major influence on LDL-C. A study performed using MetS subject from eight European countries have reported that rs290481 C allele, the major allele in that population, also contributed to higher LDL-C levels ( Delgado-Lista et al, 2010 ). Our previous study had also reported the associations of three TCF7L2 SNPs (rs7903146, rs12255372, rs10885406) with elevated TC/HDL-C ratio ( Oktavianthi et al, 2018 ). TC levels was known to be increased primarily due to elevated LDL-C levels ( Kreisberg & Kasim, 1987 ).…”

Section: Discussionmentioning

confidence: 90%

“…These findings indicated a relationship between TCF7L2 and dyslipidemia. However, the minor allele frequencies of these three SNPs were rather low in Balinese, and thus they were hard to detect ( Oktavianthi et al, 2018 ). Therefore, in the present study, we investigated the associations of other TCF7L2 intronic SNPs, rs290487 (C > T, intron 8) ( NCBI, 2021a ) and rs290481 (C > T, intron 16) ( NCBI, 2021b ), which have higher allele frequencies in East-Asian (MAF > 0.60).…”

Section: Introductionmentioning

confidence: 99%

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Transcription factor 7-like 2 single nucleotide polymorphisms rs290487 and rs290481 are associated with dyslipidemia in the Balinese population

Limardi

Oktavianthi

Priliani

et al. 2022

PeerJ

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Background Dyslipidemia is one of the major risks for the development of cardiovascular diseases which has been the leading cause of death in developing countries. Previously, common polymorphisms of the transcription factor 7-like 2 (TCF7L2) gene have been associated with altered lipid profiles. In this study, we investigated the associations of TCF7L2 SNPs, rs290487 and rs290481, with dyslipidemia and altered lipid profile in the Balinese. Methods A total of 565 subjects from four locations in the Bali Province, Indonesia, were recruited. Serum lipid concentrations (triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), total cholesterol (TC)) were measured using standard protocol. SNP genotyping was done using the amplification refractory system mutation polymerase chain reaction (ARMS-PCR) method. Results We found the shifted major/minor allele frequencies of both SNPs (0.56 for rs290487 T allele, 0.53 for rs290481 T allele) in the Balinese, as compared to dbSNP. The rs290487 and rs290481 C alleles were significantly associated with dyslipidemia, particularly high TC and high LDL-C. These associations were independent of age, sex, population, obesity, diabetes mellitus, and high TyG index as a proxy for insulin resistance. The haplotype CC also showed similar association with these traits. Our findings indicate that TCF7L2 polymorphisms are associated with dyslipidemia and altered lipid profile in the Balinese.

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Section: Discussionmentioning

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Transcription factor 7-like 2 single nucleotide polymorphisms rs290487 and rs290481 are associated with dyslipidemia in the Balinese population

Limardi

Oktavianthi

Priliani

et al. 2022

PeerJ

Self Cite

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“…The rs7903146 T-allele has been positively associated with risk for T2DM in European, 23 Indian, Thai, 24 and Iranian populations, 25 East Asian populations, namely, Japanese 26 and Chinese, 27 Turks, 28 Arabic, and Algerian, 29 African, 30 Brazilian, 31 and African American populations. 32 However, conflicting results have been reported in some studies in populations from China, Indonesia, 33 Saudi Arabia, and the United Arab Emirates, 34 Egypt, 35 as well as in a Native American population of North America, African Americans, Brazilian, 18 and Afro Caribbeans. 23 So far, the data suggest that the allelic frequencies of the rs7903146 SNP and possibly, the effect size of this SNP are variable worldwide.…”

Section: Discussionmentioning

confidence: 99%

Interaction between TCF7L2 rs7903146 Genotype, HbA1c Levels, and the Periodontal Status of Dental Patients

et al. 2021

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Objective The aim of the study was to investigate the potential interaction between TCF7L2 rs7903146 genotype, which is implicated for type-2 diabetes mellitus genetic susceptibility, HbA1c levels, and the periodontal status of dental patients. Materials and Methods HbA1c levels, clinical periodontal parameters (probing depth, clinical attachment level, bleeding on probing, and plaque index), and several parameters (such as body mass index [BMI], smoking habits, education level, and age) were recorded in 150 patients who fulfilled the criteria for screening for prediabetes/diabetes of the Centers for Disease Control and Prevention. DNA was extracted and the TCF7L2 single nucleotide polymorphism (SNP) rs7903146 was genotyped in all participants. Results Thirty-one patients out of 150 tested were found with unknown hyperglycemia (20.7%). Regarding sex, education, parent with diabetes, normal BMI, smoking, age ≥45 years and prior testing for diabetes, no differences were observed between patients displaying HbA1c < 5.7 and ≥ 5.7% (Pearson’s Chi-square test, p > 0.05). Regarding periodontal parameters and differences between subgroups (HbA1c levels ≥ 5.7 and HbA1c levels < 5.7), statistically significant differences were observed for probing depth (3.20 ± 0.94 vs. 2.81 ± 0.78 mm), clinical attachment level (3.54 ± 1.20 vs. 3.18 ± 1.06 mm) and bleeding on probing (0.62 ± 0.25 vs. 0.50 ± 0.24%) with hyperglycemic patients exhibiting worse periodontal conditions (Mann–Whitney test p < 0.05). The allelic and genotype frequencies for the transcription factor 7-like 2 (TCF7L2) gene, SNPs 7903146 did not exhibit a significant difference between the HbA1c > 5.7 and HbA1c < 5.7 groups and the periodontitis and nonperiodontitis subgroups respectively (Fisher’s exact test >0.05). Statistical Analysis Patient characteristics and their association with prediabetes were tested by Pearson’s Chi-square test (asymptotic, two sided). Differences of periodontal parameters between subgroups were tested with the Mann–Whitney U-test. The associations of allele and genotype frequencies in the patient and control groups were analyzed using the Fisher’s exact test of independence.The significance level was set at the 0.05 for all tests. Conclusion A statistically significant association between TCF7L2 rs7903146 genotype and periodontal condition or HbA1c levels was not observed in contrast to statistically significant differences of clinical parameters of periodontitis in patients with hyperglycemia.

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“…A cross-sectional study enrolling 612 participants from five locations (286 female and 326 male) in Bali Province, Indonesia, was conducted in 2008-2015 with written informed consent (Malik et al, 2011;Suastika et al, 2011b;Oktavianthi et al, 2012Oktavianthi et al, , 2018 Manuscript to be reviewed tissue (Swainson et al, 2017). The high BMI (BMI ≥25 kg/m 2 ) and high WC (male ≥ 90 cm; female ≥ cm) cut offs were according to the Asia-Pacific perspective redefining obesity in adult Asian, while the high WHtR cut off at ≥ 0.5 was based on previous reports (Lee et al, 1995;Hsieh & Yoshinaga, 1995; WHO Regional Office for the Western Pacific, 2000).…”

Section: Subjects Study Design Measurementsmentioning

confidence: 99%

Peer Review #2 of "Obesity in the Balinese is associated with FTO rs9939609 and rs1421085 single nucleotide polymorphisms (v0.1)"

2020

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Obesity prevalence is increasing worldwide, including in the Bali Province, Indonesia, a popular tourism destination area. The common single nucleotide polymorphisms (SNPs) rs9939609 and rs1421085 of the fat mass and obesity-associated (FTO) gene have been repeatedly reported as one of the important obesity genetic risk factors. We examined the associations of FTO rs9939609 and rs1421085 SNPs with obesity in the 612 unrelated Balinese subjects living in urban and rural areas. Linear and logistic regression analyses with adjustment for age and gender were employed to investigate the association between FTO genotypes, haplotypes and obesity parameters. We found that the FTO SNPs genotypes increased BMI by 1.25 kg/m 2 (p = 0.012) for rs9939609 AA and 1.12 kg/m 2 (p = 0.022) for rs1421085 CC, particularly in females and in rural population. Subjects carrying these genotypes also showed a tendency to maintain high BMI, regardless of their age. Our result showed that the FTO rs9939609 and rs1421085 risk alleles were associated with increased BMI and obesity in the Balinese.

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Transcription factor 7-like 2 single nucleotide polymorphisms are associated with lipid profile in the Balinese

Cited by 6 publications

References 44 publications

Transcription factor 7-like 2 single nucleotide polymorphisms rs290487 and rs290481 are associated with dyslipidemia in the Balinese population

Transcription factor 7-like 2 single nucleotide polymorphisms rs290487 and rs290481 are associated with dyslipidemia in the Balinese population

Interaction between TCF7L2 rs7903146 Genotype, HbA1c Levels, and the Periodontal Status of Dental Patients

Peer Review #2 of "Obesity in the Balinese is associated with FTO rs9939609 and rs1421085 single nucleotide polymorphisms (v0.1)"

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