Transcription factor 4 gene rs9960767 polymorphism in bipolar disorder

Abstract

Abstract. The transcription factor 4 (TCF4) gene encodes a helix-loop-helix transcription factor protein, which initiates neuronal differentiation and is primarily expressed during nervous system development. The aim of the present study is to investigate the association of the TCF4 rs9960767 polymorphism and bipolar disorder, which is highly heritable. DNA isolation was performed on 95 patients with bipolar disorder and 108 healthy control subjects to examine the TCF4 rs9960767 polymorphism. Genotypic and allelic frequencies were determined using the polymerase chain reaction-restriction fragment length polymorphism method designed in our laboratory. Statistical analysis was performed using χ 2 test within the 95% confidence interval. Odds ratios were calculated and Hardy-Weinberg equilibrium (HWE) was verified for all control subjects and patients. The A allele frequency was 95.8% in the patients and 94.4% in the control subjects, and 4.2% in the patients and 5.6% in the control subjects for the C allele. The genotype frequencies of the TCF4 gene rs9960767 variant were as follows: AA, 91.6% and AC, 8

Genetic Polymorphisms in miR-137 and Its Target Genes, TCF4 and CACNA1C, Contribute to the Risk of Bipolar Disorder: A Preliminary Case-Control Study and Bioinformatics Analysis

“…In a study in 2016, Deniz Ozel et al assessed genotype frequencies of the TCF4 gene rs9960767 polymorphism in 95 patients with BD and 108 healthy controls of a Turkish population. Their findings revealed that this variation does not appear to be an independent risk factor for BD; nonetheless, their findings could be biased due to the small size of the studied population [ 77 ]. Few reports have established the link between SCZ and TCF4 rs1261084C/T.…”