Transcription and Growth Regulatory Functions of the HIN-200 Family of Proteins

Johnstone, Ricky W.; Trapani, Joseph A.

doi:10.1128/mcb.19.9.5833

Cited by 114 publications

(129 citation statements)

References 43 publications

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“…One family of IFN-inducible proteins is the p200-family ( Lengyel and others 1995 ;Johnstone and Trapani 1999 ). The family includes structurally and functionally related murine and human proteins.…”

Section: The Pyrin Domainmentioning

confidence: 99%

“…Initially, we grouped these proteins in a family because all proteins contain at least one partially conserved repeat of 200-amino acid residues and referred to these proteins as p200-proteins ( Lengyel and others 1995 ). Others in the fi eld adopted a different nomenclature and named these proteins as HIN-200 (hematopoietic IFNinducible nuclear proteins with 200-amino acids) proteins ( Johnstone and Trapani 1999 ). However, several studies have provided evidence that the HIN-200 nomenclature is inappropriate: expression of several p200-family proteins is not restricted to hematopoietic cells and their expression can be regulated by numerous other signaling pathways (other than IFNs), and some proteins are both cytoplasmic and nuclear ( Choubey 2000 ;Choubey and Kotzin 2002 ;Choubey and Panchanathan 2008 ).…”

Section: The Pyrin Domainmentioning

confidence: 99%

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Interferon-Inducible p200-Family Proteins as Novel Sensors of Cytoplasmic DNA: Role in Inflammation and Autoimmunity

Choubey

Duan

Dickerson

et al. 2010

Journal of Interferon & Cytokine Research

103

131

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Deregulated innate immune responses that result in increased levels of type I interferons (IFNs) and stimulation of IFN-inducible genes are thought to contribute to chronic infl ammation and autoimmunity. One family of IFNinducible genes is the Ifi 200 family, which includes the murine (eg, Ifi 202a , Ifi 202b , Ifi 203 , Ifi 204 , Mndal , and Aim2 ) and human (eg, IFI16 , MNDA , IFIX , and AIM2 ) genes. Genes in the family encode structurally related proteins (the p200-family proteins), which share at least one partially conserved repeat of 200-amino acid (200-AA) residues. Consistent with the presence of 2 consecutive oligonucleotide/oligosaccharide-binding folds in the repeat, the p200-family proteins can bind to DNA. Additionally, these proteins (except the p202 proteins) also contain a pyrin (PYD) domain in the N-terminus. Increased expression of p202 proteins in certain strains of female mice is associated with lupus-like disease. Interestingly, only the Aim2 protein is conserved between the mouse and humans. Several recent studies have provided evidence that the Aim2 and p202 proteins can recognize DNA in cytoplasm and the Aim2 protein upon sensing DNA can form a caspase-1-activating infl ammasome. In this review, we discuss how the ability of p200-family proteins to sense cytoplasmic DNA may contribute to the development of chronic infl ammation and associated diseases.

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Section: The Pyrin Domainmentioning

confidence: 99%

Section: The Pyrin Domainmentioning

confidence: 99%

Interferon-Inducible p200-Family Proteins as Novel Sensors of Cytoplasmic DNA: Role in Inflammation and Autoimmunity

Choubey

Duan

Dickerson

et al. 2010

Journal of Interferon & Cytokine Research

103

131

View full text Add to dashboard Cite

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“…IFI16 Transcriptionally Suppresses IB␣ Expression-In addition to activating p53-dependent transcription, full-length IFI16 fused to the heterologous GAL4 DNA binding domain can act as a potent transcriptional repressor when positioned in proximity to a promoter containing GAL4 DNA elements (37,38). To further investigate the mechanisms that led to a reduction of IB␣ steady-state levels by IFI16, we first measured by real time RT-PCR IB␣ mRNA expression.…”

Section: Ifi16 Overexpression Does Not Activate the Ikk Complex But Tmentioning

confidence: 99%

A Novel Role of the Interferon-inducible Protein IFI16 as Inducer of Proinflammatory Molecules in Endothelial Cells

Caposio

Gugliesi

Zannetti

et al. 2007

Journal of Biological Chemistry

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“…These contain one or two copies of a partially conserved 200-amino-acid domain that is thought to mediate protein-protein interactions specifically with other transcription regulatory proteins. 2 Myeloid cell nuclear differentiation antigen is constitutively expressed in myelomonocytic leukemia cells, normal peripheral blood granulocytes and monocytes. 1,3,4 Although the expression of MNDA was initially thought to be restricted to the myelomonocytic lineage, several studies have shown the expression of this protein by normal and neoplastic B lymphocytes.…”

Section: Introductionmentioning

confidence: 99%

Identification of MNDA as a new marker for nodal marginal zone lymphoma

et al. 2009

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Clinical and biological studies on nodal marginal zone lymphoma (NMZL) are hampered by the lack of specific diagnostic markers and the low reproducibility of this diagnosis. A comparative expression-profiling study has shown a set of markers to be differentially expressed in NMZL compared with follicular lymphoma (FL), including myeloid cell nuclear differentiation antigen (MNDA), a nuclear protein expressed by myeloid cells and a subset of B-cells. The aim of this study was to characterize the expression of MNDA in normal and reactive human tissue, and in a large series of non-Hodgkin's B-cell lymphomas, with particular emphasis on NMZL and FL. Our results showed that MNDA is expressed in normal tissue by a subset of the marginal zone B cells. They also showed MNDA expression in subgroups of chronic lymphocytic leukemia, mantle-cell lymphoma, and diffuse large B-cell lymphoma, but MNDA was especially expressed by lymphomas derived from the marginal zone, such as mucosa-associated lymphoid-tissue lymphoma, splenic marginal-zone lymphoma and NMZL. MNDA expression was rarely observed in FL, a characteristic that is of potential value in distinguishing between NMZL and FL. MNDA expression is thus a useful tool for the recognition of NMZL.

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Transcription and Growth Regulatory Functions of the HIN-200 Family of Proteins

Cited by 114 publications

References 43 publications

Interferon-Inducible p200-Family Proteins as Novel Sensors of Cytoplasmic DNA: Role in Inflammation and Autoimmunity

Interferon-Inducible p200-Family Proteins as Novel Sensors of Cytoplasmic DNA: Role in Inflammation and Autoimmunity

A Novel Role of the Interferon-inducible Protein IFI16 as Inducer of Proinflammatory Molecules in Endothelial Cells

Identification of MNDA as a new marker for nodal marginal zone lymphoma

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