Transcranial pulsed doppler measurements of blood velocity in the middle cerebral artery: Reference values at rest and during hyperventilation in healthy volunteers in relation to age and sex

Vriens, E.M.; Kraaier, V.; Musbach, M.; Wieneke, G.H.; Huffelen, Alexander C. van

doi:10.1016/0301-5629(89)90125-7

Cited by 128 publications

(87 citation statements)

References 14 publications

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“…17 Similarly, postmenopausal women younger than age 65 years were found to have lower breath-hold indexes, indicating reduced cerebrovascular reactivity, compared to those of a group of age-matched men. 18 In contrast, we found greater cerebrovascular reactivity in females older than 65 years of age, similar to previous findings in women younger than 65 years, 6,7 whereas Vriens et al 19 found no significant difference between genders. It remains unclear why these differences exist.…”

Section: Discussionsupporting

confidence: 89%

Elderly Women Regulate Brain Blood Flow Better Than Men Do

Deegan

Sorond

Galica

et al. 2011

Stroke

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Background and Purpose-Orthostatic intolerance and falls differ between sexes and change with age. However, it remains unclear what role cerebral autoregulation may play in this response. This study was designed to determine whether cerebral autoregulation, assessed using transcranial Doppler ultrasound, is more effective in elderly females than in males. Methods-We used transcranial Doppler ultrasound to evaluate cerebral autoregulation in 544 (236 male) subjects older than age 70 years recruited as part of the MOBILIZE Boston study. The MOBILIZE Boston study is a prospective cohort study of a unique set of risk factors for falls in seniors in the Boston area. We assessed CO 2 reactivity and transfer function gain, phase, and coherence during 5 minutes of quiet sitting and autoregulatory index during sit-to-stand tests. Pϭ0.002) in the autoregulatory band, implying less effective cerebral autoregulation. However, reduced autoregulation in males was not below the normal range, indicating autoregulation was intact but less effective. Conclusions-Female subjects were better able to maintain cerebral flow velocities during postural changes and demonstrated better cerebral autoregulation. The mechanisms of sex-based differences in autoregulation remain unclear but may partially explain the higher rates of orthostatic hypotension-related hospitalizations in elderly men. (Stroke.

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Section: Discussionsupporting

confidence: 89%

Elderly Women Regulate Brain Blood Flow Better Than Men Do

Deegan

Sorond

Galica

et al. 2011

Stroke

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“…Most studies report higher mean blood flow velocities in females over males; however it is questioned whether this difference is limited to specific ages (Vriens et al 1989, Krejza et al 1999). Our findings support sex-related differences in cerebral haemodynamics where we report that females have higher CBFV compared to males and lower CrCP.…”

Section: Influence Of Sexmentioning

confidence: 99%

“…Several investigators have previously described sex-related differences in CBF in humans (Grolimund, Seiler 1988, Vriens et al 1989, Marinoni et al 1998, Muller, Schimrigk 1994, Krejza et al 1999, Deegan et al 2009), although in most cases, the number of subjects tended to be relatively small and only a few studies reported on CBFV (Deegan et al 2009). Most studies report higher mean blood flow velocities in females over males; however it is questioned whether this difference is limited to specific ages (Vriens et al 1989, Krejza et al 1999).…”

Section: Influence Of Sexmentioning

confidence: 99%

“…Using this new resource, we have extracted normative values of ARI and phase, which are the main parameters of clinical interest (Panerai 2008), and have also, tested the hypotheses that these parameters are not influenced by age and sex. These hypotheses were tested following previous observations showing effect of age and sex on CA and CBFV (Vriens et al 1989, Marinoni et al 1998). …”

Section: Introductionmentioning

confidence: 99%

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The Leicester cerebral haemodynamics database: normative values and the influence of age and sex

et al. 2016

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Normative values of physiological parameters hold significance in modern day clinical decision-making. Lack of such normative values has been a major hurdle in the translation of research into clinical practice. A large database containing uniform recordings was constructed to allow more robust estimates of normative ranges and also assess the influence of age and sex.Doppler recordings were performed on healthy volunteers in the same laboratory, using similar protocols and equipment. Beat-to-beat blood pressure, heart-rate, electrocardiogram, and end-tidal CO2 were measured continuously. Bilateral insonation of the middle cerebral arteries (MCAs) was performed using TCD following a 15-minute stabilisation, and a 5-minute baseline recording.Good quality Doppler recordings for both MCAs were obtained in 129 participants (57 female) with a median age of 57 years (range 20-82). Age was found to influence baseline haemodynamic and transfer function analysis parameters. Cerebral blood flow velocity and critical closing pressure were the only sex-related differences found, which was significantly higher in females than males.Normative values for cerebral haemodynamic parameters have been defined in a large, healthy population. Such age/sex-defined normal values can be used to reduce the burden of collecting additional control data in future studies, as well as to identify disease-associated changes. Key wordsCerebral haemodynamics, cerebral autoregulation, ageing, sex differences, cerebral blood

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“…7,8 Whereas, some studies showed that hypertension did not alter static and dynamic cerebral autoregulation. [9][10][11][12] The aim of this study is to show how blood pressure, HD and antihypertensive treatment correlate to systolic blood flow velocities (V s ) at common carotid artery (CCA), internal carotid artery (ICA) and MCA in a large population before occurrence of stroke.…”

Section: Introductionmentioning

confidence: 99%

A large-scale study on relationship between cerebral blood flow velocity and blood pressure in a natural population

Zhang

Huang

et al. 2006

J Hum Hypertens

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In order to verify the relationship between blood pressure and cerebral blood flow velocity in sub-clinical natural population, 1294 middle-aged and old Beijing rural residents were investigated in autumn 2002. For all subjects, systolic blood flow velocities (V s ) in common carotid artery (CCA), internal carotid artery (ICA) and middle cerebral artery (MCA) were detected with transcranial Doppler. Key factors such as anthropometry, medication use, blood pressure and blood biochemical analysis were investigated at the same time. After controlling for age, gender, diabetes, hypercholesterolaemia, smoking and body mass index, multivariate analysis showed that systolic blood pressure (SBP) correlated positively with V s at MCA and slight negatively correlated with at CCA. As blood pressure rose by 10 mm Hg, the V s at MCA increased by 1.63 cm/s. Duration of hypertension (HD) negatively correlated with V s at MCA (Po0.01). The V s at MCA in early-stage and chronic hypertensive patients were 92.971.9 and 84.172.3 cm/s, respectively. Antihypertensive treatment could modify the V s at MCA towards a normal level by lowering blood pressure. In conclusion, the effect of hypertension on cerebral blood flow is complex. V s at MCA positively correlated with SBP, but negatively related to HD. Antihypertensive treatment might be helpful to keep cerebral blood flow at a normal level.

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Transcranial pulsed doppler measurements of blood velocity in the middle cerebral artery: Reference values at rest and during hyperventilation in healthy volunteers in relation to age and sex

Cited by 128 publications

References 14 publications

Elderly Women Regulate Brain Blood Flow Better Than Men Do

Elderly Women Regulate Brain Blood Flow Better Than Men Do

The Leicester cerebral haemodynamics database: normative values and the influence of age and sex

A large-scale study on relationship between cerebral blood flow velocity and blood pressure in a natural population

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